Document Detail

Inhibitory activity of Filipendula ulmaria constituents on recombinant human histidine decarboxylase.
MedLine Citation:
PMID:  23411280     Owner:  NLM     Status:  In-Data-Review    
Histidine decarboxylase (HDC) catalyses the formation of histamine, a bioactive amine. Agents that control HDC activity are beneficial for treating histamine-mediated symptoms, such as allergies and stomach ulceration. We searched for inhibitors of HDC from the ethyl acetate extract of the petal of Filipendula ulmaria, also called meadowsweet. Rugosin D, rugosin A, rugosin A methyl ester (a novel compound), and tellimagrandin II were the main components; these 4 ellagitannins exhibited a non-competitive type of inhibition, with K(i) values of approximately 0.35-1μM. These K(i) values are nearly equal to that of histidine methyl ester (K(i)=0.46μM), an existing substrate analogue inhibitor. Our results show that food products contain potent HDC inhibitors and that these active food constituents might be useful for designing clinically available HDC inhibitors.
Yoko Nitta; Hiroe Kikuzaki; Toshiaki Azuma; Yuan Ye; Motoyoshi Sakaue; Yoshiki Higuchi; Hirohumi Komori; Hiroshi Ueno
Publication Detail:
Type:  Journal Article     Date:  2012-11-12
Journal Detail:
Title:  Food chemistry     Volume:  138     ISSN:  0308-8146     ISO Abbreviation:  Food Chem     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-02-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7702639     Medline TA:  Food Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  1551-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
School of Human Science and Environment, University of Hyogo, 1-1-12 Shinzaike honmachi, Himeji, Hyogo 670-0092, Japan. Electronic address:
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