Document Detail


Inhibitory action of prostaglandin E on angiotensin II-induced enhancement of vasoconstrictor response to sympathetic nerve stimulation.
MedLine Citation:
PMID:  6684189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The inhibitory action of prostaglandin E1 (PGE1) on the vasoconstrictor response to an electrical stimulation of perivascular sympathetic nerve (VSNS) was examined using the perfused central artery of an isolated rabbit ear. This response to VSNS was depressed with PGE1 (2.0 to 5.0 ng/ml in the perfusate) and was augmented with a PG synthetase inhibitor, indomethacin (1.0 microgram/ml). Angiotensin II (1.0 ng/ml) enhanced the response to VSNS, whereas treatment with PGE1 prevented the enhancing effect of angiotensin II completely. In addition, angiotensin II enhanced the response to a bolus injection of noradrenaline in an almost similar manner to that to VSNS. However, PGE1 (2.0 to 5.0 ng/ml) did not inhibit the enhancing effect of angiotensin II on the noradrenaline response. From these results, it is suggested that there may be remarkable antagonism between PGE and the sympathetic nervous system and/or the renin-angiotensin system in the central artery of the isolated rabbit ear, and that PGE1 probably and more potentially acts at presynaptic sites in perivascular sympathetic nerve endings than at postsynaptic ones.
Authors:
T Michibayashi
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  47     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-10-28     Completed Date:  1983-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1065-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alprostadil
Angiotensin II / antagonists & inhibitors*
Animals
Electric Stimulation
Indomethacin / pharmacology
Male
Phentolamine / pharmacology
Prostaglandins E / pharmacology*
Rabbits
Sympathetic Nervous System / physiology*
Tetrodotoxin / pharmacology
Vasoconstriction / drug effects*
Chemical
Reg. No./Substance:
0/Prostaglandins E; 11128-99-7/Angiotensin II; 4368-28-9/Tetrodotoxin; 50-60-2/Phentolamine; 53-86-1/Indomethacin; 745-65-3/Alprostadil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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