Document Detail

Inhibitory action of prostaglandin E on angiotensin II-induced enhancement of vasoconstrictor response to sympathetic nerve stimulation.
MedLine Citation:
PMID:  6684189     Owner:  NLM     Status:  MEDLINE    
The inhibitory action of prostaglandin E1 (PGE1) on the vasoconstrictor response to an electrical stimulation of perivascular sympathetic nerve (VSNS) was examined using the perfused central artery of an isolated rabbit ear. This response to VSNS was depressed with PGE1 (2.0 to 5.0 ng/ml in the perfusate) and was augmented with a PG synthetase inhibitor, indomethacin (1.0 microgram/ml). Angiotensin II (1.0 ng/ml) enhanced the response to VSNS, whereas treatment with PGE1 prevented the enhancing effect of angiotensin II completely. In addition, angiotensin II enhanced the response to a bolus injection of noradrenaline in an almost similar manner to that to VSNS. However, PGE1 (2.0 to 5.0 ng/ml) did not inhibit the enhancing effect of angiotensin II on the noradrenaline response. From these results, it is suggested that there may be remarkable antagonism between PGE and the sympathetic nervous system and/or the renin-angiotensin system in the central artery of the isolated rabbit ear, and that PGE1 probably and more potentially acts at presynaptic sites in perivascular sympathetic nerve endings than at postsynaptic ones.
T Michibayashi
Related Documents :
6305729 - New evidence for brain angiotensin and for its role in hypertension.
17596529 - Differential effect of tetradecythioacetic acid on the renin-angiotensin system and blo...
2438489 - Vascular angiotensin conversion in humans.
20100989 - Receptor activity-modifying protein 1 increases baroreflex sensitivity and attenuates a...
10500039 - 1166 a/c polymorphism of the angiotensin ii type 1 receptor gene and the response to sh...
6362439 - Effects on intravascular pressures of vasopressin and angiotensin ii in dogs.
3974129 - Roles of coronary circulation as a determinant of the left ventriculo-arterial interact...
7458029 - Evaluation of blood pressure during early alcohol withdrawal.
2009699 - Does tortuosity in cerebral arterioles impair down-autoregulation in hypertensives and ...
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  47     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-10-28     Completed Date:  1983-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1065-70     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Angiotensin II / antagonists & inhibitors*
Electric Stimulation
Indomethacin / pharmacology
Phentolamine / pharmacology
Prostaglandins E / pharmacology*
Sympathetic Nervous System / physiology*
Tetrodotoxin / pharmacology
Vasoconstriction / drug effects*
Reg. No./Substance:
0/Prostaglandins E; 11128-99-7/Angiotensin II; 4368-28-9/Tetrodotoxin; 50-60-2/Phentolamine; 53-86-1/Indomethacin; 745-65-3/Alprostadil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Treatment and surgical staging of testicular and primary extragonadal germ cell cancer.
Next Document:  A new approach for assessment of narcotic physical dependence using urinary sex-dependent low molecu...