| Inhibitory action of antioxidants (ascorbic acid or alpha-tocopherol) on seizures and brain damage induced by pilocarpine in rats. | |
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MedLine Citation:
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PMID: 20602035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Temporal lobe epilepsy is the most common form of epilepsy in humans. Oxidative stress is a mechanism of cell death induced by seizures. Antioxidant compounds have neuroprotective effects due to their ability to inhibit free radical production. The objectives of this work were to comparatively study the inhibitory action of antioxidants (ascorbic acid or alpha-tocopherol) on behavioral changes and brain damage induced by high doses of pilocarpine, aiming to further clarify the mechanism of action of these antioxidant compounds. In order to determinate neuroprotective effects, we studied the effects of ascorbic acid (250 or 500 mg/kg, i.p.) and alpha-tocopherol (200 or 400 mg/kg, i.p.) on the behavior and brain lesions observed after seizures induced by pilocarpine (400 mg/kg, i.p., P400 model) in rats. Ascorbic acid or alpha-tocopherol injections prior to pilocarpine suppressed behavioral seizure episodes. These findings suggested that free radicals can be produced during brain damage induced by seizures. In the P400 model, ascorbic acid and alpha-tocopherol significantly decreased cerebral damage percentage. Antioxidant compounds can exert neuroprotective effects associated with inhibition of free radical production. These results highlighted the promising therapeutic potential of ascorbic acid and alpha-tocopherol in treatments for neurodegenerative diseases. |
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Authors:
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Adriana da Rocha Tomé; Paulo Michel Pinheiro Ferreira; Rivelilson Mendes de Freitas |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Arquivos de neuro-psiquiatria Volume: 68 ISSN: 1678-4227 ISO Abbreviation: Arq Neuropsiquiatr Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-05 Completed Date: 2011-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0125444 Medline TA: Arq Neuropsiquiatr Country: Brazil |
Other Details:
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Languages: eng Pagination: 355-61 Citation Subset: IM |
Affiliation:
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State University of Ceará, Fortaleza, CE, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / therapeutic use* Ascorbic Acid / therapeutic use* Brain Damage, Chronic / etiology, pathology, prevention & control* Hippocampus / drug effects, pathology Male Muscarinic Agonists Neuroprotective Agents / therapeutic use* Pilocarpine Rats Rats, Wistar Seizures / chemically induced, complications, prevention & control* alpha-Tocopherol / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Muscarinic Agonists; 0/Neuroprotective Agents; 50-81-7/Ascorbic Acid; 59-02-9/alpha-Tocopherol; 92-13-7/Pilocarpine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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