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Inhibitory Effects of Terpenoids from the Fermented Broth of the Ascomycete Stilbohypoxylon elaeicola YMJ173 on Nitric Oxide Production in RAW264.7 Macrophages.
MedLine Citation:
PMID:  22253110     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
A series of six isopimarane-type diterpene glycosides, along with an eremophilane-type sesquiterpene, i.e., elaeicolasides A-C (1-3, resp.), 16-(α-D-mannopyranosyloxy)isopimar-7-en-19-oic acid (4), hymatoxin K (5), hymatoxin L (6), and elaeicolalactone (7), were isolated from the AcOEt extract of the fermented broth of Stilbohypoxylon elaeicola YMJ173. Among these, 1-3 and 7 are new compounds based on their spectroscopic data and sugar composition analysis. The effects of 1-7 on the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cells were evaluated. All these compounds inhibited NO production, detected as nitrite in the culture medium, in activated macrophages without any cytotoxicity at a concentration of 100 μM. Among these compounds, 2 showed a significant activity with the average maximum inhibition (E(max) ) and median inhibitory concentration (IC(50) ) values of 93.3±0.5% and 79.3±0.4 μM, respectively.
Authors:
Guei-Jane Wang; Wen-Li Liang; Yu-Ming Ju; Wen-Bin Yang; Ya-Wen Chang; Tzong-Huei Lee
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemistry & biodiversity     Volume:  9     ISSN:  1612-1880     ISO Abbreviation:  Chem. Biodivers.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101197449     Medline TA:  Chem Biodivers     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  131-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Verlag Helvetica Chimica Acta AG, Zürich.
Affiliation:
L5 Research Center, China Medical University Hospital, Taichung 404, Taiwan.
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