Document Detail

Inhibitory effects of fatty acids on the activity of mushroom tyrosinase.
MedLine Citation:
PMID:  20544305     Owner:  NLM     Status:  MEDLINE    
The effects of fatty acids, octanoic acid, (2E, 4E)-hexa-2,4-dienoic acid, hexanoic acid, (2E)-but-2-enoic acid, and butyric acid on the activities of mushroom tyrosinase have been investigated. The results showed that the fatty acids can potently inhibit both monophenolase activity and diphenolase activity of tyrosinase, and that the unsaturated fatty acids exhibited stronger inhibitory effect against tyrosinase than the corresponding saturated fatty acids, and the inhibitory effects were enhanced with the extendability of the fatty acid chain. For the monophenolase activity, the fatty acids could not only lengthen the lag period, but also decrease the steady-state activities. For the diphenolase activity, fatty acids displayed reversible inhibition. Kinetic analyses showed that octanoic acid and hexanoic acid were mixed-type inhibitors and (2E,4E)-hexa-2,4-dienoic acid and (2E)-but-2-enoic acid were noncompetitive inhibitors. The inhibition constants have been determined and compared.
Yun-Ji Guo; Zhi-Zhen Pan; Chao-Qi Chen; Yong-Hua Hu; Feng-Jiao Liu; Yan Shi; Jiang-Hua Yan; Qing-Xi Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-11
Journal Detail:
Title:  Applied biochemistry and biotechnology     Volume:  162     ISSN:  1559-0291     ISO Abbreviation:  Appl. Biochem. Biotechnol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-08-30     Completed Date:  2010-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8208561     Medline TA:  Appl Biochem Biotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1564-73     Citation Subset:  IM    
Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen, China.
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MeSH Terms
Agaricales / enzymology*
Enzyme Inhibitors / chemistry,  pharmacology*
Fatty Acids / chemistry,  pharmacology*
Fungal Proteins / antagonists & inhibitors*,  metabolism*
Monophenol Monooxygenase / antagonists & inhibitors*,  metabolism*
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Fatty Acids; 0/Fungal Proteins; EC Monooxygenase

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