Document Detail

Inhibitory effect of TIMP influences the morphology of varicose veins.
MedLine Citation:
PMID:  20598922     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Imbalance of matrix metalloproteinase enzymes (MMP) and their inhibitors (TIMPs) may contribute to the development of varicose veins. We hypothesised that, histological changes in varicose vein wall correlate with alterations in expression of MMP/TIMP.
METHODS: Varicose veins (n=26) were compared with great saphenous vein (GSV) segments (n=11) from arterial bypass, and with arm and neck veins from fistula and carotid operations (n=13). Varicose vein wall thickness was measured, enabling categorisation as atrophic and hypertrophic. MMP-2, MT1-MMP, TIMP-2, and TIMP-3 expression were quantitatively analysed by immunohistochemistry.
RESULTS: There was significantly higher expression of TIMP-2 (immunopositive area 4.34% versus 0.26%), linked with connective tissue accumulation in the tunica media of varicose veins as compared with arm and neck vein controls. TIMP-2 and TIMP-3 expression was higher in hypertrophic than atrophic segments (3.2% versus 0.99% for TIMP-2, 1.7% versus 0.08% for TIMP-3). Similarly, TIMP-2 and TIMP-3 had elevated expression in the thicker proximal varicose vein segments compared to distal (4.3% versus 1.3% for TIMP-2 and 0.94% versus 0.41% for TIMP-3).
CONCLUSIONS: This study linked morphological changes in varicose vein walls with MMP/TIMP balance. A higher TIMP expression favours deposition of connective tissue and thus thicker vein wall, reducing matrix turnover by suppression of protease activity.
B Aravind; B Saunders; T Navin; A Sandison; C Monaco; E M Paleolog; A H Davies
Publication Detail:
Type:  Journal Article     Date:  2010-07-03
Journal Detail:
Title:  European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery     Volume:  40     ISSN:  1532-2165     ISO Abbreviation:  Eur J Vasc Endovasc Surg     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-29     Completed Date:  2011-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9512728     Medline TA:  Eur J Vasc Endovasc Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  754-65     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.
Department of Surgery and Cancer, Faculty of Medicine, Imperial College, and Department of Histopathology, Charing Cross Hospital, London, UK.
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MeSH Terms
Aged, 80 and over
Case-Control Studies
Connective Tissue / chemistry,  pathology
Cross-Sectional Studies
Matrix Metalloproteinase 14 / analysis
Matrix Metalloproteinase 2 / analysis
Middle Aged
Tissue Inhibitor of Metalloproteinase-2 / analysis*
Tissue Inhibitor of Metalloproteinase-3 / analysis*
Tunica Media / chemistry,  pathology
Varicose Veins / metabolism*,  pathology
Veins / chemistry*,  pathology
Young Adult
Reg. No./Substance:
0/TIMP3 protein, human; 0/Tissue Inhibitor of Metalloproteinase-3; 127497-59-0/Tissue Inhibitor of Metalloproteinase-2; EC protein, human; EC Metalloproteinase 2; EC protein, human; EC Metalloproteinase 14

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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