Document Detail

Inhibitors of rat renin and their use in experimental hypertension.
MedLine Citation:
PMID:  2698930     Owner:  NLM     Status:  MEDLINE    
Hydroxy-ethylene dipeptide analogues (Leu[CH(OH)-CH2]Leu and Leu[CH(OH)-CH2]Val) of human substrate peptides are potent in vitro inhibitors of rat renin with IC50 values as low as 0.8 nmol/l. When given to renal hypertensive rats they lower blood pressure and suppress both plasma renin and angiotensin II. There was a divergence between the rapid rebound of renin and blood pressure which remained suppressed.
E C Beattie; J J Morton; B J Leckie; J Sueiras-Diaz; D M Jones; M Szelke
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hypertension. Supplement : official journal of the International Society of Hypertension     Volume:  7     ISSN:  0952-1178     ISO Abbreviation:  J Hypertens Suppl     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-05-11     Completed Date:  1990-05-11     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8501422     Medline TA:  J Hypertens Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S220-1     Citation Subset:  IM    
MRC Blood Pressure Unit, Western Infirmary, Glasgow, UK.
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MeSH Terms
Blood Pressure / drug effects,  physiology
Drug Evaluation, Preclinical
Hypertension / blood,  drug therapy*,  etiology,  physiopathology
Oligopeptides / therapeutic use*
Renin / antagonists & inhibitors*,  blood
Time Factors
Reg. No./Substance:
0/Oligopeptides; 75645-19-1/renin inhibitory peptide; EC

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