| Inhibitors of protein glycosylation inhibit the differentiation of Friend erythroleukemia cells. | |
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MedLine Citation:
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PMID: 7066327 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tunicamycin, 2-deoxy-D-glucose and 2-deoxy-2-fluoro-D-glucose inhibit dimethyl sulfoxide-induced differentiation of Friend cells. This inhibition, characterized by inhibition of hemoglobin synthesis, is accompanied by a specific inhibition of protein glycosylation. The results of cloning experiments indicate that this inhibition specifically affects cells in the period preceding their commitment. These results suggest that glycoprotein synthesis is a requirement for Friend erythroleukemia cells in order to initiate the expression of the terminal differentiation program. |
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Authors:
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G J Bosman; P Boer; E P Steyn-Parvé |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 696 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1982 Mar |
Date Detail:
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Created Date: 1982-06-21 Completed Date: 1982-06-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 285-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation / drug effects Cell Line Deoxyglucose / analogs & derivatives, pharmacology Fluorodeoxyglucose F18 Glycoproteins / biosynthesis* Leukemia, Experimental / physiopathology* Mice Neoplasm Proteins / metabolism* Tunicamycin / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Glycoproteins; 0/Neoplasm Proteins; 11089-65-9/Tunicamycin; 154-17-6/Deoxyglucose; 63503-12-8/Fluorodeoxyglucose F18 |
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