Document Detail


Inhibitors of fatty acid synthesis in prokaryotes and eukaryotes as anti-infective, anticancer and anti-obesity drugs.
MedLine Citation:
PMID:  22709254     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
There is a large range of diseases, such diabetes and cancer, which are connected to abnormal fatty acid metabolism in human cells. Therefore, inhibitors of human fatty acid synthase have great potential to manage or treat these diseases. In prokaryotes, fatty acid synthesis is important for signaling, as well as providing starting materials for the synthesis of phospholipids, which are required for the formation of the cell membrane. Recently, there has been renewed interest in the development of new molecules that target bacterial fatty acid synthases for the treatment of bacterial diseases. In this review, we look at the differences and similarities between fatty acid synthesis in humans and bacteria and highlight various small molecules that have been shown to inhibit either the mammalian or bacterial fatty acid synthase or both.
Authors:
Jingxin Wang; Ryan Hudson; Herman O Sintim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Future medicinal chemistry     Volume:  4     ISSN:  1756-8927     ISO Abbreviation:  Future Med Chem     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101511162     Medline TA:  Future Med Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  1113-51     Citation Subset:  IM    
Affiliation:
Department of Chemistry & Biochemistry, University of Maryland, College Park, MD 20742, USA.
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