Document Detail


Inhibitors of fatty acid synthesis as antimicrobial chemotherapeutics.
MedLine Citation:
PMID:  12021787     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fatty acid biosynthesis is an emerging target for the development of novel antibacterial chemotherapeutics. The dissociated bacterial system is substantially different from the large, multifunctional protein of mammals, and many possibilities exist for type-selective drugs. Several compounds, both synthetic and natural, target bacterial fatty acid synthesis. Three compounds target the FabI enoyl-ACP reductase step; isoniazid, a clinically used antituberculosis drug, triclosan, a widely used consumer antimicrobial, and diazaborines. In addition, cerulenin and thiolactomycin, two fungal products, inhibit the FabH, FabB and FabF condensation enzymes. Finally, the synthetic reaction intermediates BP1 and decynoyl- N-acetyl cysteamine inhibit the acetyl-CoA carboxylase and dehydratase isomerase steps, respectively. The mechanisms of action of these compounds, as well as the potential development of new drugs targeted against this pathway, are discussed.
Authors:
R J Heath; S W White; C O Rock
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review     Date:  2002-03-07
Journal Detail:
Title:  Applied microbiology and biotechnology     Volume:  58     ISSN:  0175-7598     ISO Abbreviation:  Appl. Microbiol. Biotechnol.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-05-21     Completed Date:  2002-07-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8406612     Medline TA:  Appl Microbiol Biotechnol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  695-703     Citation Subset:  IM    
Affiliation:
Protein Science Division, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis TN 38105, USA. richard.heath@stjude.org
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MeSH Terms
Descriptor/Qualifier:
Anti-Infective Agents / pharmacology*
Enzymes / metabolism
Fatty Acids / antagonists & inhibitors*,  biosynthesis
Grant Support
ID/Acronym/Agency:
CA 21765/CA/NCI NIH HHS; GM 34496/GM/NIGMS NIH HHS; GM44973/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Infective Agents; 0/Enzymes; 0/Fatty Acids

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