| Inhibitors of the oncogenic transcription factor AP-1 from Podocarpus latifolius. | |
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MedLine Citation:
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PMID: 21306129 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An activator protein-1 (AP-1) based bioassay-guided phytochemical investigation on Podocarpus latifolius led to the isolation of three new sempervirol-type diterpenes, cycloinumakiol (1), inumakal (2), and inumakoic acid (3), along with three known norditerpenes (4-6). Compounds 4 and 6 were responsible for the observed bioactivity. |
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Authors:
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Krishna P Devkota; Ranjala Ratnayake; Nancy H Colburn; Jennifer A Wilson; Curtis J Henrich; James B McMahon; John A Beutler |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural Date: 2011-02-09 |
Journal Detail:
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Title: Journal of natural products Volume: 74 ISSN: 1520-6025 ISO Abbreviation: J. Nat. Prod. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-25 Completed Date: 2011-06-02 Revised Date: 2012-03-29 |
Medline Journal Info:
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Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: United States |
Other Details:
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Languages: eng Pagination: 374-7 Citation Subset: IM |
Affiliation:
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Molecular Targets Laboratory, Molecular Discovery Program, National Cancer Institute, Frederick, Maryland 21702, United States. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Diterpenes
/
chemistry,
isolation & purification*,
pharmacology* Humans Molecular Structure Pinaceae / chemistry* Plant Bark / chemistry Plant Roots / chemistry Tanzania Transcription Factor AP-1 / antagonists & inhibitors* |
| Grant Support | |
ID/Acronym/Agency:
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HHSN261200800001E//PHS HHS; Z99 CA999999/CA/NCI NIH HHS; ZIC BC010469-08/BC/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/11,10-oxymethylenecyclopent-14-isopropyl-8,11,13-podocarpatriene; 0/11-hydroxy-14-isopropyl-8,11,13-podocarpatrien-19-al; 0/11-hydroxy-14-isopropyl-8,11,13-podocarpatrien-19-oic acid; 0/Diterpenes; 0/Transcription Factor AP-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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