Document Detail


Inhibitors of the oncogenic transcription factor AP-1 from Podocarpus latifolius.
MedLine Citation:
PMID:  21306129     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An activator protein-1 (AP-1) based bioassay-guided phytochemical investigation on Podocarpus latifolius led to the isolation of three new sempervirol-type diterpenes, cycloinumakiol (1), inumakal (2), and inumakoic acid (3), along with three known norditerpenes (4-6). Compounds 4 and 6 were responsible for the observed bioactivity.
Authors:
Krishna P Devkota; Ranjala Ratnayake; Nancy H Colburn; Jennifer A Wilson; Curtis J Henrich; James B McMahon; John A Beutler
Related Documents :
24819689 - Gas chromatography-mass spectrometry analysis of fatty acid profiles of antarctic and n...
23445319 - A double-enzyme coupled assay for high-throughput screening of succinic acid producing ...
17573659 - Amino acid profile in cassava and its interspecific hybrid.
17884209 - Tracing 2,4-d metabolism in cupriavidus necator jmp134 with 13c-labelling technique and...
11894099 - An amino-acid taste receptor.
6208329 - Posttranslational protein modification by amino acid addition in intact and regeneratin...
17392489 - Membrane lipid composition of pancreatic ar42j cells: modification by exposure to diffe...
9124489 - Bicarbonate and co2 transport across the skin of the leopard frog, rana pipiens: effect...
1115249 - Cold resistance of the brain during hibernation. iii. evidence of a lipid adaptation.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2011-02-09
Journal Detail:
Title:  Journal of natural products     Volume:  74     ISSN:  1520-6025     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-25     Completed Date:  2011-06-02     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  374-7     Citation Subset:  IM    
Affiliation:
Molecular Targets Laboratory, Molecular Discovery Program, National Cancer Institute, Frederick, Maryland 21702, United States.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Diterpenes / chemistry,  isolation & purification*,  pharmacology*
Humans
Molecular Structure
Pinaceae / chemistry*
Plant Bark / chemistry
Plant Roots / chemistry
Tanzania
Transcription Factor AP-1 / antagonists & inhibitors*
Grant Support
ID/Acronym/Agency:
HHSN261200800001E//PHS HHS; Z99 CA999999/CA/NCI NIH HHS; ZIC BC010469-08/BC/NCI NIH HHS
Chemical
Reg. No./Substance:
0/11,10-oxymethylenecyclopent-14-isopropyl-8,11,13-podocarpatriene; 0/11-hydroxy-14-isopropyl-8,11,13-podocarpatrien-19-al; 0/11-hydroxy-14-isopropyl-8,11,13-podocarpatrien-19-oic acid; 0/Diterpenes; 0/Transcription Factor AP-1
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Gradient Solvent Vapor Annealing of Block Copolymer Thin Films Using a Microfluidic Mixing Device.
Next Document:  Total Synthesis of Citridone A.