Document Detail

Inhibitors of the oncogenic transcription factor AP-1 from Podocarpus latifolius.
MedLine Citation:
PMID:  21306129     Owner:  NLM     Status:  MEDLINE    
An activator protein-1 (AP-1) based bioassay-guided phytochemical investigation on Podocarpus latifolius led to the isolation of three new sempervirol-type diterpenes, cycloinumakiol (1), inumakal (2), and inumakoic acid (3), along with three known norditerpenes (4-6). Compounds 4 and 6 were responsible for the observed bioactivity.
Krishna P Devkota; Ranjala Ratnayake; Nancy H Colburn; Jennifer A Wilson; Curtis J Henrich; James B McMahon; John A Beutler
Related Documents :
16034169 - Effects of eu3+ on the metabolism of amino acid and protein in xerophytic lathyrus sati...
23098619 - Erythrocyte stearidonic acid and other n-3 fatty acids and chd in the physicians' healt...
6849309 - Decreased incorporation of 14c-glucosamine relative to 3h-n-acetyl glucosamine in the i...
6572939 - Beta-hydroxyaspartic acid in vitamin k-dependent protein c.
3748119 - Plasteins. their preparation, properties, and use in nutrition.
8390859 - Improved synthetic methods for the selective deuteration of aromatic amino acids: appli...
3063069 - Effect of vitamin a on bone resorption: evidence for direct stimulation of isolated chi...
6406679 - Metabolism of cadaverine and pipecolic acid in brain and other organs of the mouse.
14995149 - The composition of grain and forage from glyphosate tolerant wheat mon 71800 is equival...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2011-02-09
Journal Detail:
Title:  Journal of natural products     Volume:  74     ISSN:  1520-6025     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-25     Completed Date:  2011-06-02     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  374-7     Citation Subset:  IM    
Molecular Targets Laboratory, Molecular Discovery Program, National Cancer Institute, Frederick, Maryland 21702, United States.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Diterpenes / chemistry,  isolation & purification*,  pharmacology*
Molecular Structure
Pinaceae / chemistry*
Plant Bark / chemistry
Plant Roots / chemistry
Transcription Factor AP-1 / antagonists & inhibitors*
Grant Support
HHSN261200800001E//PHS HHS; Z99 CA999999/CA/NCI NIH HHS; ZIC BC010469-08/BC/NCI NIH HHS
Reg. No./Substance:
0/11,10-oxymethylenecyclopent-14-isopropyl-8,11,13-podocarpatriene; 0/11-hydroxy-14-isopropyl-8,11,13-podocarpatrien-19-al; 0/11-hydroxy-14-isopropyl-8,11,13-podocarpatrien-19-oic acid; 0/Diterpenes; 0/Transcription Factor AP-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Gradient Solvent Vapor Annealing of Block Copolymer Thin Films Using a Microfluidic Mixing Device.
Next Document:  Total Synthesis of Citridone A.