Document Detail

Inhibitors of the oncogenic transcription factor AP-1 from Podocarpus latifolius.
MedLine Citation:
PMID:  21306129     Owner:  NLM     Status:  MEDLINE    
An activator protein-1 (AP-1) based bioassay-guided phytochemical investigation on Podocarpus latifolius led to the isolation of three new sempervirol-type diterpenes, cycloinumakiol (1), inumakal (2), and inumakoic acid (3), along with three known norditerpenes (4-6). Compounds 4 and 6 were responsible for the observed bioactivity.
Krishna P Devkota; Ranjala Ratnayake; Nancy H Colburn; Jennifer A Wilson; Curtis J Henrich; James B McMahon; John A Beutler
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2011-02-09
Journal Detail:
Title:  Journal of natural products     Volume:  74     ISSN:  1520-6025     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-25     Completed Date:  2011-06-02     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  374-7     Citation Subset:  IM    
Molecular Targets Laboratory, Molecular Discovery Program, National Cancer Institute, Frederick, Maryland 21702, United States.
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MeSH Terms
Diterpenes / chemistry,  isolation & purification*,  pharmacology*
Molecular Structure
Pinaceae / chemistry*
Plant Bark / chemistry
Plant Roots / chemistry
Transcription Factor AP-1 / antagonists & inhibitors*
Grant Support
HHSN261200800001E//PHS HHS; Z99 CA999999/CA/NCI NIH HHS; ZIC BC010469-08/BC/NCI NIH HHS
Reg. No./Substance:
0/11,10-oxymethylenecyclopent-14-isopropyl-8,11,13-podocarpatriene; 0/11-hydroxy-14-isopropyl-8,11,13-podocarpatrien-19-al; 0/11-hydroxy-14-isopropyl-8,11,13-podocarpatrien-19-oic acid; 0/Diterpenes; 0/Transcription Factor AP-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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