Document Detail


Inhibitors of Bacterial Transcription are Compounds for Potent Antimicrobial Drugs.
MedLine Citation:
PMID:  24809716     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The increasing resistance of microorganisms against antibiotics available on the pharmaceutical market is now a global problem. There is an incessant necessity to search for new, effective treatments against resistant strains of microorganisms, for new potent classes of antibiotics with novel modes of action targeted at important components of microbial cells. Such a critical, essential system for cell functioning is a RNA polymerase (RNAP), an enzyme that catalyses one of the stages of gene expression: transcription. RNAP is a proven target for a number of antibiotics, and it still remains an attractive drug target for new potent antimicrobial compounds. In this review several examples of inhibitors for transcription initiation and RNAP are presented.
Authors:
Katarzyna Turecka; Krzysztof Waleron
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-08
Journal Detail:
Title:  Current pharmaceutical biotechnology     Volume:  -     ISSN:  1873-4316     ISO Abbreviation:  Curr Pharm Biotechnol     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100960530     Medline TA:  Curr Pharm Biotechnol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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