| Inhibitor incidence after intensive FVIII replacement for surgery in mild and moderate haemophilia A: a prospective national study in the Netherlands. | |
| | |
MedLine Citation:
|
PMID: 22533635 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
SUMMARY: Inhibitor development is currently the most severe complication in mild/moderate haemophilia A patients, causing increased bleeding tendency, hospitalization and mortality. It has been suggested that receiving high doses of factor VIII (FVIII) concentrates for surgical procedures is an important risk factor for inhibitor development in these patients. The current multicentre study aimed to determine prospectively the incidence of inhibitor development after intensive FVIII replacement therapy for surgical procedures in patients with mild/moderate haemophilia A. All consecutive patients with mild/moderate haemophilia A were included when they required at least 10 000 iu of FVIII concentrates (or 250 iu/kg) for 5 or more days for a surgical procedure. Potential clinical risk factors for inhibitor development and results of inhibitor tests were collected. Forty-six patients with a median age of 54 years (interquartile range, 40-59 years) were included in the study. F8 genotyping revealed 20 different missense mutations. Patients received either recombinant (65%) or plasma-derived FVIII concentrates (35%) by intermittent bolus injections (41%) or continuous infusion (57%). Two patients developed a low titre inhibitor post-operatively. The incidence of inhibitor development following intensive treatment for surgery in this unselected prospective cohort of mild/moderate haemophilia A patients was 4% (95% confidence interval, 0·5-14·8). |
| | |
Authors:
|
Corien L Eckhardt; Evelien P Mauser-Bunschoten; Marjolein Peters; Frank W G Leebeek; Felix J M van der Meer; Karin Fijnvandraat |
Related Documents
:
|
9971855 - Which endometrial polyps should be resected? 22915885 - Regional block anesthesia in a patient with factor v leiden mutation and axillary arter... 8498945 - The residual adnexa syndrome. 389675 - Current status of hysteroscopy in gynecologic practice. 10429785 - Microvascular reconstruction of the head and neck after tumor ablation. 21801995 - Portal venous remodeling after endovascular reduction of pediatric autogenous portosyst... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-4-26 |
Journal Detail:
|
Title: British journal of haematology Volume: - ISSN: 1365-2141 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
|
Created Date: 2012-4-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2012 Blackwell Publishing Ltd. |
Affiliation:
|
Department of Paediatric Haematology, Emma Children's Hospital, Academic Medical Centre, Amsterdam, the Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: GeoChip-based analysis of microbial functional gene diversity in a landfill leachate-contaminated aq...
Next Document: Understanding the origins and prevalence of AIDS conspiracy beliefs in the United States and South A...