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The APC/C Inhibitor XErp1/Emi2 Is Essential for Xenopus Early Embryonic Divisions.
MedLine Citation:
PMID:  23019610     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Mitotic divisions result from the oscillating activity of cyclin-dependent kinase-1 (Cdk1). Cdk1 activity is terminated by the anaphase-promoting-complex/cyclosome (APC/C), a ubiquitin-ligase that targets cyclin-B for destruction. In somatic divisions, Emi1 and the spindle-assembly-checkpoint (SAC) regulate cell-cycle progression by inhibiting the APC/C. Early embryonic divisions lack these APC/C-inhibitory components, raising the question of how these cycles are controlled. Here, we found that the APC/C-inhibitory activity of XErp1/Emi2 was essential for early divisions in Xenopus embryos. Loss of XErp1 resulted in untimely destruction of APC/C-substrates and embryonic lethality. XErp1's APC/C-inhibitory function was negatively regulated by Cdk1 and positively by protein-phosphatase-2A (PP2A). Thus, Cdk1 and PP2A are at the core of early mitotic cell-cycles by antagonistically controlling XErp1-activity resulting in oscillating APC/C activity.
Authors:
Thomas Tischer; Eva Hörmanseder; Thomas U Mayer
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-27
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  -     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Biology and Konstanz Research School Chemical Biology, University of Konstanz, Universitätsstr. 10, 78457 Konstanz, Germany.
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