Document Detail

Inhibition of the zymosan-induced chemiluminescence of human phagocytes by adenosine, polyadenylic acid and agents influencing adenosine metabolism.
MedLine Citation:
PMID:  2554706     Owner:  NLM     Status:  MEDLINE    
The zymosan-induced chemiluminescence of human phagocytes (neutrophil granulocytes) could be inhibited by adenosine, polyadenylic acid, dipyridamole (an agent blocking the cellular adenosine uptake) and coformycin (a highly potent inhibitor of enzyme adenosine deaminase). It is suggested that in estimating the antianginal and antithrombotic action of dipyridamole, its action on the phagocytes should be taken into account. The same consideration would be true for 2'-deoxycoformycin (a coformycin analogue) used as a potent anticancer and immunosuppressive drug.
S Sipka; A J Szentmiklósi; A Nagy; V Taskov; G Szegedi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Allergologia et immunopathologia     Volume:  17     ISSN:  0301-0546     ISO Abbreviation:  Allergol Immunopathol (Madr)     Publication Date:    1989 Jul-Aug
Date Detail:
Created Date:  1989-12-20     Completed Date:  1989-12-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370073     Medline TA:  Allergol Immunopathol (Madr)     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  209-12     Citation Subset:  IM    
3rd Department of Internal Medicine, University Medical School of Debrecen, Hungary.
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MeSH Terms
Adenosine / metabolism,  pharmacology*
Coformycin / pharmacology*
Dipyridamole / pharmacology*
Luminescent Measurements*
Neutrophils / drug effects*,  physiology
Poly A / pharmacology*
Receptors, Purinergic / drug effects
Superoxides / metabolism
Zymosan / antagonists & inhibitors*
Reg. No./Substance:
0/Receptors, Purinergic; 11033-22-0/Coformycin; 11062-77-4/Superoxides; 24937-83-5/Poly A; 58-32-2/Dipyridamole; 58-61-7/Adenosine; 9010-72-4/Zymosan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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