| Inhibition of the zymosan-induced chemiluminescence of human phagocytes by adenosine, polyadenylic acid and agents influencing adenosine metabolism. | |
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MedLine Citation:
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PMID: 2554706 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The zymosan-induced chemiluminescence of human phagocytes (neutrophil granulocytes) could be inhibited by adenosine, polyadenylic acid, dipyridamole (an agent blocking the cellular adenosine uptake) and coformycin (a highly potent inhibitor of enzyme adenosine deaminase). It is suggested that in estimating the antianginal and antithrombotic action of dipyridamole, its action on the phagocytes should be taken into account. The same consideration would be true for 2'-deoxycoformycin (a coformycin analogue) used as a potent anticancer and immunosuppressive drug. |
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Authors:
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S Sipka; A J Szentmiklósi; A Nagy; V Taskov; G Szegedi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Allergologia et immunopathologia Volume: 17 ISSN: 0301-0546 ISO Abbreviation: Allergol Immunopathol (Madr) Publication Date: 1989 Jul-Aug |
Date Detail:
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Created Date: 1989-12-20 Completed Date: 1989-12-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370073 Medline TA: Allergol Immunopathol (Madr) Country: SPAIN |
Other Details:
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Languages: eng Pagination: 209-12 Citation Subset: IM |
Affiliation:
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3rd Department of Internal Medicine, University Medical School of Debrecen, Hungary. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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metabolism,
pharmacology* Coformycin / pharmacology* Dipyridamole / pharmacology* Humans Luminescent Measurements* Neutrophils / drug effects*, physiology Poly A / pharmacology* Receptors, Purinergic / drug effects Superoxides / metabolism Zymosan / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Purinergic; 11033-22-0/Coformycin; 11062-77-4/Superoxides; 24937-83-5/Poly A; 58-32-2/Dipyridamole; 58-61-7/Adenosine; 9010-72-4/Zymosan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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