Document Detail

Inhibition of vesicular stomatitis virus replication by poly(2'-fluoro-2'-deoxyuridylic acid).
MedLine Citation:
PMID:  174488     Owner:  NLM     Status:  MEDLINE    
Poly(2'-fluoro-2'-deoxyuridylic acid) is known to be an effective inhibitor of the deoxyribonucleic acid polymerase found within the oncornaviruses. This synthetic polynucleotide was found to inhibit the replication of vesicular stomatitis virus in mouse L cells. The polymer was shown to be capable of inhibiting the viral ribonucleic acid (RNA)-dependent RNA polymerase, and it is proposed that this is the mechanism of antiviral activity. The following observations support this viewpoint: (i) the polymer is most active when added after virus adsorption; (ii) the antiviral activity is not species specific; and (iii) the polynucleotide is nontoxic to the host cell. Conventional methodologies designed to increase nucleic acid uptake by cultured cells do not show an increase in antiviral potency.
J C Grosch; R J Erickson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  8     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1975 Nov 
Date Detail:
Created Date:  1976-03-18     Completed Date:  1976-03-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  544-50     Citation Subset:  IM    
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MeSH Terms
DNA-Directed RNA Polymerases / metabolism
Depression, Chemical
Fluorodeoxyuridylate / pharmacology
L Cells (Cell Line)
Poly U / analogs & derivatives*,  pharmacology
Vesicular stomatitis Indiana virus / drug effects*,  enzymology
Virus Replication / drug effects*
Reg. No./Substance:
134-46-3/Fluorodeoxyuridylate; 27416-86-0/Poly U; EC RNA Polymerases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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