Document Detail


Inhibition of vesicular stomatitis virus replication by poly(2'-fluoro-2'-deoxyuridylic acid).
MedLine Citation:
PMID:  174488     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Poly(2'-fluoro-2'-deoxyuridylic acid) is known to be an effective inhibitor of the deoxyribonucleic acid polymerase found within the oncornaviruses. This synthetic polynucleotide was found to inhibit the replication of vesicular stomatitis virus in mouse L cells. The polymer was shown to be capable of inhibiting the viral ribonucleic acid (RNA)-dependent RNA polymerase, and it is proposed that this is the mechanism of antiviral activity. The following observations support this viewpoint: (i) the polymer is most active when added after virus adsorption; (ii) the antiviral activity is not species specific; and (iii) the polynucleotide is nontoxic to the host cell. Conventional methodologies designed to increase nucleic acid uptake by cultured cells do not show an increase in antiviral potency.
Authors:
J C Grosch; R J Erickson
Related Documents :
791108 - Tirandamycin, an inhibitor of bacterial ribonucleic acid polymerase.
169228 - Transient repression of catabolite-sensitive enzyme synthesis elicited by 2,4-dinitroph...
2696428 - Membrane fatty acid and virulence changes in the viable but nonculturable state of vibr...
24420478 - Macrocyclic lactones and isopentenyl esters in the dufour's gland secretion of halictin...
15553158 - Investigation of the elemental composition and chemical association of several elements...
19824618 - Aspergillusol a, an alpha-glucosidase inhibitor from the marine-derived fungus aspergil...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  8     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1975 Nov 
Date Detail:
Created Date:  1976-03-18     Completed Date:  1976-03-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  544-50     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cricetinae
DNA-Directed RNA Polymerases / metabolism
Depression, Chemical
Fluorodeoxyuridylate / pharmacology
L Cells (Cell Line)
Mice
Poly U / analogs & derivatives*,  pharmacology
Vesicular stomatitis Indiana virus / drug effects*,  enzymology
Virus Replication / drug effects*
Chemical
Reg. No./Substance:
134-46-3/Fluorodeoxyuridylate; 27416-86-0/Poly U; EC 2.7.7.6/DNA-Directed RNA Polymerases
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Study of the interaction of human serum albumin with penicillins by means of spin labels
Next Document:  Prospective double-blind evaluation of topical adenine arabinoside in male herpes progenitalis.