Document Detail


Inhibition of tumor cell invasion in the Boyden chamber assay by a mannosidase inhibitor, mannostatin A.
MedLine Citation:
PMID:  8239514     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An alpha-mannosidase inhibitor, mannostatin A, from Streptoverticillium verticillus var. quintum inhibited chemotactic invasion of mouse B16/F10 melanoma cells in the Boyden chamber assay. It also inhibited in vitro invasion of K-ras-NIH3T3 cells. Mannostatin A did not inhibit the growth of either cell line at the concentration effective to inhibit invasion. Addition of mannostatin A to the cultured B16/F10 or K-ras-NIH3T3 cells inhibited cellular alpha-mannoside activity specifically. Mannostatin A-treated B16/F10 cells also showed decreased metastatic activity in vivo in C57Bl/6 mice.
Authors:
Y Ochi; S Atsumi; T Aoyagi; K Umezawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  13     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1993 Sep-Oct
Date Detail:
Created Date:  1993-12-17     Completed Date:  1993-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  1421-4     Citation Subset:  IM    
Affiliation:
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.
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MeSH Terms
Descriptor/Qualifier:
3T3 Cells
Animals
Cyclopentanes / pharmacology*
Diffusion Chambers, Culture
Female
Lung Neoplasms / prevention & control,  secondary
Mannosidases / antagonists & inhibitors*
Melanoma / pathology*,  prevention & control,  secondary
Mice
Mice, Inbred C57BL
Neoplasm Invasiveness
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Cyclopentanes; 102822-56-0/mannostatin A; EC 3.2.1.-/Mannosidases

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