| Inhibition of the G2/M transition of the cell cycle by methyl-2,5-dihydroxycinnamate in human lymphoid cells. | |
| | |
MedLine Citation:
|
PMID: 8753796 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Immortalized human lymphoid cells treated with Methyl-2,5-dihydroxycinnamate (MDHC), a stable analog of erbstatin, inhibited the G2/M transition of the cell cycle. The MDHC inhibition of the cell cycle was observed at concentrations well below the IC50 for the inhibition of the EGF receptor and sufficiently below that reported to induce protein cross-linking. The effect of MDHC upon the cell cycle is relatively stable, since unlike erbstatin, inhibition of the G2/M transition was observed 32 hours following removal of the drug. PHA stimulated human peripheral blood mononuclear cells (PBMC) were much less sensitive to MDHC. This study shows that MDHC acts on cells lacking an EGF receptor and the target of MDHC is involved in promoting progression of the cell cycle. |
| | |
Authors:
|
J A Koch; K S Rosenthal; J M Jamison; J L Summers |
Related Documents
:
|
15576926 - The c. elegans cell cycle: overview of molecules and mechanisms. 15375296 - Formulated glyphosate activates the dna-response checkpoint of the cell cycle leading t... 2699326 - Rise in intracellular ph is concurrent with 'start' progression of saccharomyces cerevi... 12325006 - Cell cycle control and cell division: implications for chemically induced carcinogenesis. 7881546 - Analysis of saccharomyces cerevisiae proteins induced by peroxide and superoxide stress. 9168666 - Immunohistochemical aspects of chromogranins in endocrine cells of the duodenal mucosa ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Biochemical and biophysical research communications Volume: 225 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1996 Aug |
Date Detail:
|
Created Date: 1996-10-10 Completed Date: 1996-10-10 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 531-6 Citation Subset: IM |
Affiliation:
|
Department of Microbiology, Immunology and Urology, Northeastern Ohio Universities College of Medicine, Rootstown 44272, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cell Line Cell Line, Transformed Cinnamates / pharmacology* G2 Phase / drug effects* Humans Lymphocytes / cytology, drug effects* Mitosis / drug effects* Monocytes / cytology, drug effects Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
|
0/Cinnamates; 63177-57-1/methyl 2,5-dihydroxycinnamate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prevention of the expression of inducible nitric oxide synthase by aminoguanidine or aminoethyl-isot...
Next Document: Specific orientation of porphyrin at the binding site of catalytic antibody.