Document Detail

Inhibition of suxamethonium relaxation by tubocurarine and gallamine pretreatment during induction of anaesthesia in man.
MedLine Citation:
PMID:  1106738     Owner:  NLM     Status:  MEDLINE    
The effect of tubocurarine and gallamine pretreatments on suxamethonium relaxation was measured in 81 patients. The blocking effect of a constant infusion of suxamethonium (0.58 mg/sec) on the recorded thumb adduction in response to supramaximal ulnar nerve stimulation was reproducible in 18 control subjects: infusion time for 50% block was 37.7 (+/- SEM 1.02) sec. Tubocurarine 3 mg and 6 mg increased the infusion time required to produce 50% block by 33.4 and 54.8% respectively. Gallamine had a similar effect. Clinical conditions for endotracheal intubation were evaluated on a blind basis. Both drugs produced impairment of clinical conditions for intubation after suxamethonium 60 mg infusion. However, when pretreatment by tubocurarine 3 mg was followed by suxamethonium infusion at 1 mg/sec the time course of neuromuscular blockade was identical to that of the controls. There were no fasciculations with this dosage and conditions for endotracheal intubation were excellent.
A L Pauca; R C Reynolds; G E Strobel
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  47     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1975 Oct 
Date Detail:
Created Date:  1976-03-30     Completed Date:  1976-03-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1067-73     Citation Subset:  IM    
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MeSH Terms
Clinical Trials as Topic
Gallamine Triethiodide / pharmacology*
Intubation, Intratracheal
Middle Aged
Muscle Contraction / drug effects
Preanesthetic Medication*
Succinylcholine / antagonists & inhibitors*
Time Factors
Tubocurarine / pharmacology*
Reg. No./Substance:
306-40-1/Succinylcholine; 57-95-4/Tubocurarine; 65-29-2/Gallamine Triethiodide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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