Document Detail


Inhibition of suxamethonium relaxation by tubocurarine and gallamine pretreatment during induction of anaesthesia in man.
MedLine Citation:
PMID:  1106738     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of tubocurarine and gallamine pretreatments on suxamethonium relaxation was measured in 81 patients. The blocking effect of a constant infusion of suxamethonium (0.58 mg/sec) on the recorded thumb adduction in response to supramaximal ulnar nerve stimulation was reproducible in 18 control subjects: infusion time for 50% block was 37.7 (+/- SEM 1.02) sec. Tubocurarine 3 mg and 6 mg increased the infusion time required to produce 50% block by 33.4 and 54.8% respectively. Gallamine had a similar effect. Clinical conditions for endotracheal intubation were evaluated on a blind basis. Both drugs produced impairment of clinical conditions for intubation after suxamethonium 60 mg infusion. However, when pretreatment by tubocurarine 3 mg was followed by suxamethonium infusion at 1 mg/sec the time course of neuromuscular blockade was identical to that of the controls. There were no fasciculations with this dosage and conditions for endotracheal intubation were excellent.
Authors:
A L Pauca; R C Reynolds; G E Strobel
Related Documents :
7486038 - Antagonism of mivacurium neuromuscular block: neostigmine versus edrophonium.
3213388 - Influence of age on the dose-response relationship of atracurium in paediatric patients.
19650798 - Infusion requirements and reversibility of rocuronium at the corrugator supercilii and ...
8075858 - Mechanisms of sympathetic enhancement and inhibition of parasympathetically induced sal...
21194178 - Effect of 2,4-dihydroxybenzophenone (bp1) on early life-stage development of the marine...
2312878 - Treatment of staphylococcus aureus mastitis with penicillin and novobiocin: antibiotic ...
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  47     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1975 Oct 
Date Detail:
Created Date:  1976-03-30     Completed Date:  1976-03-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1067-73     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Clinical Trials as Topic
Female
Gallamine Triethiodide / pharmacology*
Humans
Intubation, Intratracheal
Middle Aged
Muscle Contraction / drug effects
Preanesthetic Medication*
Succinylcholine / antagonists & inhibitors*
Time Factors
Tubocurarine / pharmacology*
Chemical
Reg. No./Substance:
306-40-1/Succinylcholine; 57-95-4/Tubocurarine; 65-29-2/Gallamine Triethiodide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The interaction of tubocurarine and suxamethonium at different stages of recovery from tubocurarine-...
Next Document:  Evaluation of etidocaine in extradural block.