Document Detail

Inhibition of survival signalling by dietary polyphenols and indole-3-carbinol.
MedLine Citation:
PMID:  16087329     Owner:  NLM     Status:  MEDLINE    
Epidemiological studies have long hinted at the possibility that what we eat greatly influences our state of health, in particular our relative risk of developing cancer. In recent years there has been an exponential increase in the number of studies investigating how individual components of the diet interact at the molecular level to determine the fate of a cell. It is now apparent that many such molecules can preferentially inhibit the growth of tumour cells, by inducing cell cycle arrest or apoptosis. The number of signalling pathways and molecular targets involved is continually expanding. Consequently, the picture is becoming ever more complicated, not least because results often appear to be cell-type specific, dose-response relationships are critical, and any one agent appears to have multiple mechanisms of action. In addition most studies have been conducted in cell culture, often with physiologically unachievable concentrations of single agents, making extrapolation to the clinical situation difficult. In this review the mechanisms of action of a few well-studied dietary polyphenols (curcumin, epigallocatechin gallate and resveratrol) and indole-3 carbinol are considered in the light of these issues.
Margaret M Manson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of cancer (Oxford, England : 1990)     Volume:  41     ISSN:  0959-8049     ISO Abbreviation:  Eur. J. Cancer     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-05     Completed Date:  2005-11-28     Revised Date:  2011-11-02    
Medline Journal Info:
Nlm Unique ID:  9005373     Medline TA:  Eur J Cancer     Country:  England    
Other Details:
Languages:  eng     Pagination:  1842-53     Citation Subset:  IM    
Cancer Biomarkers and Prevention Group, Department of Biochemistry, Biocentre, University of Leicester, University Road, Leicester LE1 7RH, UK.
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MeSH Terms
Catechin / analogs & derivatives,  pharmacology
Cell Cycle
Curcumin / pharmacology
Flavonoids / administration & dosage,  pharmacology*
Indoles / administration & dosage,  pharmacology*
Mitogen-Activated Protein Kinases / pharmacology
Neoplasms / metabolism*
Phenols / administration & dosage,  pharmacology*
Protein-Serine-Threonine Kinases / pharmacology
STAT Transcription Factors / pharmacology
Signal Transduction / drug effects*
Reg. No./Substance:
0/Flavonoids; 0/Indoles; 0/Phenols; 0/STAT Transcription Factors; 0/polyphenols; 154-23-4/Catechin; 458-37-7/Curcumin; 700-06-1/indole-3-carbinol; 989-51-5/epigallocatechin gallate; EC Kinases; EC Protein Kinases; EC B kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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