| Inhibition of stimulant-induced activation of phagocytic cells with tetrandrine. | |
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MedLine Citation:
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PMID: 1655939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tetrandrine is an alkaloid obtained from the root of a medicinal herb which is employed in China as a treatment for silicosis. One proposed mechanism for the development of silica-induced fibrosis is lung damage resulting from particle-induced inflammation and secretion of reactive compounds from alveolar phagocytes. Therefore, the objective of the present study was to determine if tetrandrine exhibited the ability to inhibit respiratory burst activity of pulmonary phagocytes. The data indicate that although tetrandrine is not cytotoxic to phagocytic cells, it is a potent inhibitor in vitro of zymosan-stimulated oxygen consumption, superoxide anion release, and hydrogen peroxide secretion by alveolar macrophages. Tetrandrine is also effective in vivo in preventing activation of alveolar macrophages after inhalation or intratracheal instillation of silica. Tetrandrine also inhibits stimulant-induced chemiluminescence by polymorphonuclear leukocytes. Since tetrandrine does not alter stimulant-induced depolarization of phagocytic cells, its inhibitory action is not via interference with receptor-ligand binding but rather must occur elsewhere in the stimulus-secretion coupling scheme. |
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Authors:
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V Castranova; J H Kang; M D Moore; W H Pailes; D G Frazer; D Schwegler-Berry |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of leukocyte biology Volume: 50 ISSN: 0741-5400 ISO Abbreviation: J. Leukoc. Biol. Publication Date: 1991 Oct |
Date Detail:
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Created Date: 1991-10-31 Completed Date: 1991-10-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8405628 Medline TA: J Leukoc Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 412-22 Citation Subset: IM |
Affiliation:
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Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alkaloids
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pharmacology* Animals Anti-Inflammatory Agents, Non-Steroidal / pharmacology* Benzylisoquinolines* Hydrogen Peroxide / metabolism Luminescent Measurements Male Neutrophils / drug effects, physiology Oxygen Consumption / drug effects Phagocytes / drug effects*, metabolism, physiology Phagocytosis / drug effects*, physiology Rats Rats, Inbred Strains Superoxides / metabolism Zymosan / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Alkaloids; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Benzylisoquinolines; 11062-77-4/Superoxides; 518-34-3/tetrandrine; 7722-84-1/Hydrogen Peroxide; 9010-72-4/Zymosan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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