Document Detail

Inhibition of sterol biosynthesis by ergosterol and cholesterol in Saccharomyces cerevisiae.
MedLine Citation:
PMID:  3896318     Owner:  NLM     Status:  MEDLINE    
When accumulation of squalene was used as a measure of the flow of carbon into the sterol pathway in whole cells of semi-anaerobic Saccharomyces cerevisiae, both ergosterol and cholesterol were found to be inhibitory. However, at equivalent concentrations in the medium ergosterol was substantially the more potent inhibitor. Marked differences found in the absorption and esterification of the two sterols failed to account for the observed difference in their capacities to act as feedback agents. Cholesterol was much more effectively absorbed as well as esterified, but, when the abilities of the two sterols to lower the squalene level were calculated on the basis of free sterol in the cells, ergosterol remained more effective by a factor of four.
W J Pinto; R Lozano; W R Nes
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  836     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-10-08     Completed Date:  1985-10-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  89-95     Citation Subset:  IM    
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MeSH Terms
Cholesterol / pharmacology*
Ergosterol / pharmacology*
Gas Chromatography-Mass Spectrometry
Saccharomyces cerevisiae / metabolism*
Squalene / metabolism
Sterols / biosynthesis*
Grant Support
Reg. No./Substance:
0/Sterols; 111-02-4/Squalene; 57-87-4/Ergosterol; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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