| Inhibition of starch digestion by the green tea polyphenol, (-)-epigallocatechin-3-gallate. | |
| | |
MedLine Citation:
|
PMID: 23038646 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
SCOPE: Green tea has been shown to ameliorate symptoms of metabolic syndrome in vivo. The effects could be due, in part, to modulation of postprandial blood glucose levels. METHODS AND RESULTS: We examined the effect of coadministration of (-)-epigallocatechin-3-gallate (EGCG, 100 mg/kg, i.g.) on blood glucose levels following oral administration of common corn starch (CCS), maltose, sucrose, or glucose to fasted CF-1 mice. We found that cotreatment with EGCG significantly reduced postprandial blood glucose levels after administration of CCS compared to control mice (50 and 20% reduction in peak blood glucose levels and blood glucose area under the curve, respectively). EGCG had no effect on postprandial blood glucose following administration of maltose or glucose, suggesting that EGCG may modulate amylase-mediated starch digestion. In vitro, EGCG noncompetitively inhibited pancreatic amylase activity by 34% at 20 μM. No significant change was induced in the expression of two small intestinal glucose transporters (GLUT2 and SGLT1). CONCLUSIONS: Our results suggest that EGCG acutely reduces postprandial blood glucose levels in mice when coadministered with CCS and this may be due in part to inhibition of α-amylase. The relatively low effective dose of EGCG makes a compelling case for studies in human subjects. |
| | |
Authors:
|
Sarah C Forester; Yeyi Gu; Joshua D Lambert |
Related Documents
:
|
19246576 - Diabetes in african american youth: prevalence, incidence, and clinical characteristics... 18388336 - Regional differences in diabetes as a possible contributor to the geographic disparity ... 12894056 - Diabetes prevalence among american indians and alaska natives and the overall populatio... 17493546 - Ethnic differences in the frequency of enpp1/pc1 121q genetic variant in the dallas hea... 16722026 - What is the optimal dwell time for maximizing ultrafiltration with icodextrin exchange ... 21983986 - Abated microrna-195 expression protected mesangial cells from apoptosis in early diabet... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-10-05 |
Journal Detail:
|
Title: Molecular nutrition & food research Volume: 56 ISSN: 1613-4133 ISO Abbreviation: Mol Nutr Food Res Publication Date: 2012 Nov |
Date Detail:
|
Created Date: 2012-10-25 Completed Date: 2013-04-25 Revised Date: 2013-06-17 |
Medline Journal Info:
|
Nlm Unique ID: 101231818 Medline TA: Mol Nutr Food Res Country: Germany |
Other Details:
|
Languages: eng Pagination: 1647-54 Citation Subset: IM |
Copyright Information:
|
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
|
Center of Excellence for Plant and Mushroom Foods for Health, Department of Food Science, The Pennsylvania State University, University Park, PA 16802, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Amylases / metabolism Animals Area Under Curve Blood Glucose / analysis, metabolism* Catechin / administration & dosage, analogs & derivatives*, pharmacology Dose-Response Relationship, Drug Glucose Transporter Type 2 / metabolism Intestine, Small / drug effects, metabolism Male Mice Pancreatic alpha-Amylases / antagonists & inhibitors, metabolism Postprandial Period Sodium-Glucose Transporter 1 / metabolism Starch / administration & dosage, metabolism, pharmacokinetics* Tea / chemistry |
| Grant Support | |
ID/Acronym/Agency:
|
AT004678/AT/NCCAM NIH HHS; R01 AT004678/AT/NCCAM NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 0/Glucose Transporter Type 2; 0/Slc2a2 protein, mouse; 0/Slc5a1 protein, mouse; 0/Sodium-Glucose Transporter 1; 0/Tea; 154-23-4/Catechin; 9005-25-8/Starch; BQM438CTEL/epigallocatechin gallate; EC 3.2.1.-/Amylases; EC 3.2.1.1/Pancreatic alpha-Amylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The neurobiology and neural circuitry of cognitive changes in Parkinson's disease revealed by functi...
Next Document: The effect of pulsed electromagnetic fields and dehydroepiandrosterone on viability and osteo-induct...