Document Detail


Inhibition of starch digestion by the green tea polyphenol, (-)-epigallocatechin-3-gallate.
MedLine Citation:
PMID:  23038646     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
SCOPE: Green tea has been shown to ameliorate symptoms of metabolic syndrome in vivo. The effects could be due, in part, to modulation of postprandial blood glucose levels.
METHODS AND RESULTS: We examined the effect of coadministration of (-)-epigallocatechin-3-gallate (EGCG, 100 mg/kg, i.g.) on blood glucose levels following oral administration of common corn starch (CCS), maltose, sucrose, or glucose to fasted CF-1 mice. We found that cotreatment with EGCG significantly reduced postprandial blood glucose levels after administration of CCS compared to control mice (50 and 20% reduction in peak blood glucose levels and blood glucose area under the curve, respectively). EGCG had no effect on postprandial blood glucose following administration of maltose or glucose, suggesting that EGCG may modulate amylase-mediated starch digestion. In vitro, EGCG noncompetitively inhibited pancreatic amylase activity by 34% at 20 μM. No significant change was induced in the expression of two small intestinal glucose transporters (GLUT2 and SGLT1).
CONCLUSIONS: Our results suggest that EGCG acutely reduces postprandial blood glucose levels in mice when coadministered with CCS and this may be due in part to inhibition of α-amylase. The relatively low effective dose of EGCG makes a compelling case for studies in human subjects.
Authors:
Sarah C Forester; Yeyi Gu; Joshua D Lambert
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-10-05
Journal Detail:
Title:  Molecular nutrition & food research     Volume:  56     ISSN:  1613-4133     ISO Abbreviation:  Mol Nutr Food Res     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-25     Completed Date:  2013-04-25     Revised Date:  2013-11-01    
Medline Journal Info:
Nlm Unique ID:  101231818     Medline TA:  Mol Nutr Food Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1647-54     Citation Subset:  IM    
Copyright Information:
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Center of Excellence for Plant and Mushroom Foods for Health, Department of Food Science, The Pennsylvania State University, University Park, PA 16802, USA.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Amylases / metabolism
Animals
Area Under Curve
Blood Glucose / analysis,  metabolism*
Catechin / administration & dosage,  analogs & derivatives*,  pharmacology
Dose-Response Relationship, Drug
Glucose Transporter Type 2 / metabolism
Intestine, Small / drug effects,  metabolism
Male
Mice
Pancreatic alpha-Amylases / antagonists & inhibitors,  metabolism
Postprandial Period
Sodium-Glucose Transporter 1 / metabolism
Starch / administration & dosage,  metabolism,  pharmacokinetics*
Tea / chemistry
Grant Support
ID/Acronym/Agency:
AT004678/AT/NCCAM NIH HHS; R01 AT004678/AT/NCCAM NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Glucose Transporter Type 2; 0/Slc2a2 protein, mouse; 0/Slc5a1 protein, mouse; 0/Sodium-Glucose Transporter 1; 0/Tea; 154-23-4/Catechin; 9005-25-8/Starch; BQM438CTEL/epigallocatechin gallate; EC 3.2.1.-/Amylases; EC 3.2.1.1/Pancreatic alpha-Amylases
Comments/Corrections

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