Document Detail

Inhibition of sporulation in Bacillus subtilis by bromodeoxyuridine and the effect on DNA replication.
MedLine Citation:
PMID:  3086498     Owner:  NLM     Status:  MEDLINE    
A 5-bromo-2'-deoxyuridine (BUdR)-tolerant derivative of a thymidine (TdR)-requiring strain of Bacillus subtilis was used to examine the effect of BUdR, an analogue of TdR, on sporulation. At a TdR:BUdR ratio which had little effect on growth, sporulation was inhibited if cells were exposed to BUdR during the period of DNA synthesis at the onset of the process. Cells recovered from BUdR inhibition of sporulation if the analogue was removed and DNA replication allowed to continue with TdR alone. BUdR prolonged the period of DNA synthesis during sporulation and experiments with chloramphenicol suggested that this was due in part to unscheduled initiation of new rounds of replication.
C Binnie; J G Coote
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of general microbiology     Volume:  132     ISSN:  0022-1287     ISO Abbreviation:  J. Gen. Microbiol.     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-07-10     Completed Date:  1986-07-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375371     Medline TA:  J Gen Microbiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  493-502     Citation Subset:  IM    
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MeSH Terms
Bacillus subtilis / drug effects,  physiology*
Bromodeoxyuridine / pharmacology*
Chloramphenicol / pharmacology
DNA Replication / drug effects
Deoxycytidine / pharmacology
Genetic Markers
Hydroxyphenylazouracil / pharmacology
Spores, Bacterial / drug effects
Uridine / pharmacology
Reg. No./Substance:
0/Genetic Markers; 29050-86-0/Hydroxyphenylazouracil; 56-75-7/Chloramphenicol; 58-96-8/Uridine; 59-14-3/Bromodeoxyuridine; 951-77-9/Deoxycytidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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