Document Detail

Inhibition of rostral medullary raphé neurons prevents cold-induced activity in sympathetic nerves to rat tail and rabbit ear arteries.
MedLine Citation:
PMID:  15036613     Owner:  NLM     Status:  MEDLINE    
Sympathetically-mediated vasoconstriction of cutaneous vessels is critical for thermoregulation in the cold. We determined whether cold-induced sympathetic discharge depends on activity of neurons in the rostral medullary raphé. In urethane-anesthetized rats and rabbits, cooling the trunk skin by a water jacket reproducibly increased cutaneous sympathetic discharge recorded in the tail (rats) and the ear pinna (rabbits). When neurons in the rostral medullary raphé were inhibited by microinjection of glycine (30-100 nmol in 60-200 nl in rats), or muscimol (1 nmol in 100 nl in rabbits), cutaneous sympathetic activity was silenced and no longer responded to cooling (7+/-3 and 5+/-2% of pre-injection increase in rats and rabbits, respectively, P < 0.01). Our data demonstrate that activity of rostral medullary raphé neurons is important for the CNS mediation of cold-induced increases in sympathetic cutaneous vasomotor nerves.
Youichirou Ootsuka; William W Blessing; Robin M McAllen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  357     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-03-23     Completed Date:  2004-06-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  58-62     Citation Subset:  IM    
Department of Human Physiology, School of Medicine, Centre for Neuroscience, Flinders University, Bedford Park, SA 5042, Australia.
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MeSH Terms
Action Potentials / drug effects,  physiology
Arteries / innervation*,  physiology
Blood Pressure / drug effects,  physiology
Body Temperature / drug effects,  physiology
Body Temperature Regulation / drug effects,  physiology
Cold Temperature / adverse effects
Ear / blood supply,  physiology
GABA Agonists / pharmacology
Glycine / pharmacology
Medulla Oblongata / cytology,  drug effects,  physiology*
Muscimol / pharmacology
Neural Inhibition / drug effects,  physiology
Neurons / physiology
Raphe Nuclei / cytology,  drug effects,  physiology*
Rats, Sprague-Dawley
Regional Blood Flow / drug effects,  physiology*
Skin / blood supply
Sympathetic Fibers, Postganglionic / physiology*
Tail / blood supply,  physiology
Vasomotor System / drug effects,  physiology*
Reg. No./Substance:
0/GABA Agonists; 2763-96-4/Muscimol; 56-40-6/Glycine

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