Document Detail

Inhibition of renin secretion in the isolated rat kidney by antidiuretic hormone.
MedLine Citation:
PMID:  1149397     Owner:  NLM     Status:  MEDLINE    
1. The effect of antidiuretic hormone (ADH) on isoprenaline-stimulated renin secretion was examined in the isolated rat kidney perfused with modified Krebs-Ringer saline. 2. Intrarenal infusion OF ADH effectively prevented stimulation of renin secretion by isoprenaline whilst increasing renal perfusion pressure. 3. The exclusion of calcium ions from the perfusion medium abolished the vasoconstrictor effect of ADH and attenuated the inhibitory effect of ADH on isoprenaline-stimulated renin secretion. However, significant suppression of renin secretion was still apparent compared with experiments where isoprenaline was infused alone. 4. These observations indicate that ADH inhibits renin secretion and that this is effected by a direct action on the kidney. Although this may be partly mediated by the rise in renal perfusion pressure, an additional direct effect of ADH on the renin-producing cell, which is dependent on the availability of calcium ions, is proposed.
R Vandongen
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Clinical science and molecular medicine     Volume:  49     ISSN:  0301-0538     ISO Abbreviation:  Clin Sci Mol Med     Publication Date:  1975 Jul 
Date Detail:
Created Date:  1975-10-30     Completed Date:  1975-10-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367540     Medline TA:  Clin Sci Mol Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  73-6     Citation Subset:  IM    
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MeSH Terms
Calcium / pharmacology
Isoproterenol / pharmacology
Kidney / drug effects,  secretion*
Renin / secretion*
Time Factors
Vasopressins / pharmacology*
Reg. No./Substance:
11000-17-2/Vasopressins; 7440-70-2/Calcium; 7683-59-2/Isoproterenol; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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