| Inhibition of renin by plasma linoleic acid. | |
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MedLine Citation:
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PMID: 3052059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The authors have demonstrated previously that human plasma contains an inhibitor(s) of the enzymatic activity of renin. The purpose of this study is to identify the circulating renin inhibitor. Plasma initially was fractionated with preparative sephacryl S-300 chromatography. A fraction with low protein content inhibited the in vitro enzymatic activity of human renin by 76%. The inhibitory activity of this fraction was not altered by boiling and/or acidification. This fraction was applied to an affinity column, using purified mouse submaxillary renin as ligand. The inhibitor was recovered after elution with hypertonic NaCl. Linoleic acid, a previously identified renin inhibitor, was present in this fraction. The authors conclude that circulating linoleic acid inhibits renin. Conceivably, the overall activity of the renin-angiotensin-aldosterone cascade may be modified by alterations of plasma fatty acid concentrations. |
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Authors:
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R T Talwalkar; T A Kotchen |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of the medical sciences Volume: 296 ISSN: 0002-9629 ISO Abbreviation: Am. J. Med. Sci. Publication Date: 1988 Sep |
Date Detail:
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Created Date: 1988-11-18 Completed Date: 1988-11-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 192-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University of Kentucky, School of Medicine, Lexington. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin I
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biosynthesis Animals Chromatography / methods Female Humans Linoleic Acids / blood, pharmacology* Mice Renin / antagonists & inhibitors*, blood Submandibular Gland / enzymology |
| Grant Support | |
ID/Acronym/Agency:
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HL32126/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Linoleic Acids; 9041-90-1/Angiotensin I; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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