Document Detail

Inhibition of the renin-angiotensin system: no effect on circulating macrophage colony-stimulating factor levels in acute myocardial infarction.
MedLine Citation:
PMID:  12827024     Owner:  NLM     Status:  MEDLINE    
Macrophage colony-stimulating factor, which induces proliferation and differentiation, and activation of monocytes and macrophages, plays an important role in the vulnerability of atheromatous plaques as well as the formation of atherosclerotic lesions. We measured serum concentrations of macrophage colony-stimulating factor in patients with acute myocardial infarction and also investigated the effects of early administration of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker on circulating macrophage colony-stimulating factor levels in these patients. The patients were divided randomly into 3 therapeutic groups; perindopril, candesartan, and control (without perindopril and candesartan) groups, and the drugs were administered within 24 to 36 hours after the onset of acute myocardial infarction. Serum macrophage colony-stimulating factor concentrations in acute myocardial infarction patients at the time of admission were significantly higher than those in healthy control subjects. The macrophage colony-stimulating factor levels in the patients decreased gradually after admission, but remained significantly higher than those in control subjects for 14 days. There were no significant differences in serum macrophage colony-stimulating factor levels among the 3 therapeutic groups during this study period. In conclusion, circulating macrophage colony-stimulating factor levels are elevated during the course of acute myocardial infarction, and inhibition of the renin-angiotensin system by angiotensin-converting enzyme inhibitor or angiotensin receptor blocker does not affect these levels.
Kenji Kurosaki; Uichi Ikeda; Yoshiaki Murakami; Masafumi Takahashi; Kazuyuki Shimada
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  42     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-06-26     Completed Date:  2003-11-21     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  37-41     Citation Subset:  IM    
Division of Cardiovascular Medicine, Jichi Medical School, Tochigi, Japan.
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MeSH Terms
Aged, 80 and over
Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors / administration & dosage,  therapeutic use
Antihypertensive Agents / administration & dosage,  therapeutic use*
Benzimidazoles / administration & dosage,  therapeutic use
Macrophage Colony-Stimulating Factor / blood*
Middle Aged
Myocardial Infarction / blood,  drug therapy*,  metabolism
Perindopril / administration & dosage,  therapeutic use
Renin-Angiotensin System / drug effects*
Tetrazoles / administration & dosage,  therapeutic use
Treatment Outcome
Reg. No./Substance:
0/Angiotensin Receptor Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Benzimidazoles; 0/Tetrazoles; 81627-83-0/Macrophage Colony-Stimulating Factor; 82834-16-0/Perindopril; S8Q36MD2XX/candesartan

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