| Inhibition of renal membrane binding and nephrotoxicity of gentamicin by polyasparagine and polyaspartic acid in the rat. | |
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MedLine Citation:
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PMID: 3838817 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of the polyamino acids, polylysine, polyasparagine and polyaspartic acid, on 3H-gentamicin binding to rat renal brush border membranes was observed. All three polyamino acids showed inhibition of 3H-gentamicin binding at 1X and 0.1X the molar amount of gentamicin. Polylysine, polyasparagine and polyaspartic acid were subsequently tested in vivo for potential nephroprotective activity vs. gentamicin in a 14-day subacute nephrotoxicity model at 3X, 0.5X and 0.3X the molar dose of gentamicin, respectively. While polylysine did not produce significant nephroprotection, polyasparagine and polyaspartic acid completely eliminated gentamicin-induced nephrotoxicity. |
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Authors:
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P D Williams; G H Hottendorf |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Research communications in chemical pathology and pharmacology Volume: 47 ISSN: 0034-5164 ISO Abbreviation: Res. Commun. Chem. Pathol. Pharmacol. Publication Date: 1985 Feb |
Date Detail:
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Created Date: 1985-06-10 Completed Date: 1985-06-10 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0244734 Medline TA: Res Commun Chem Pathol Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 317-20 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Gentamicins / metabolism, toxicity* Kidney / drug effects*, metabolism Male Peptides / pharmacology* Polylysine / pharmacology Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Gentamicins; 0/Peptides; 25104-18-1/Polylysine; 26063-13-8/polyaspartate; 26894-34-8/polyasparagine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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