| Inhibition of rat platelet 5-hydroxytryptamine uptake by chlordimeform. | |
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MedLine Citation:
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PMID: 7302966 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chlordimeform, a formamidine insecticide and acaricide, and two of its toxic N-demethyl metabolites inhibited rat blood platelet 5-hydroxytryptamine (5-HT) uptake. A direct relationship existed between formamidine uptake inhibitory potency and N-demethylation. Didemethylchlordimeform, the most potent formamidine inhibitor of 5-HT uptake examined, had a pI50 of 4.2. However, it was appreciably less active than the classical inhibitor imipramine, which yielded 86.4% inhibition of 5-HT uptake at a concentration of 1.10(-5) M. |
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Authors:
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T L Johnson; C O Knowles |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Toxicology letters Volume: 9 ISSN: 0378-4274 ISO Abbreviation: Toxicol. Lett. Publication Date: 1981 Sep |
Date Detail:
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Created Date: 1982-01-09 Completed Date: 1982-01-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7709027 Medline TA: Toxicol Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 1-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amidines
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pharmacology* Animals Blood Platelets / drug effects, metabolism* Chlorphenamidine / pharmacology* Depression, Chemical Imipramine / pharmacology Male Rats Rats, Inbred Strains Serotonin / blood* |
| Grant Support | |
ID/Acronym/Agency:
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ES01316/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amidines; 50-49-7/Imipramine; 50-67-9/Serotonin; 6164-98-3/Chlorphenamidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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