Document Detail

Inhibition of rat lens aldose reductase by quercetagetin and patuletin.
MedLine Citation:
PMID:  1843126     Owner:  NLM     Status:  MEDLINE    
In this paper the results of inhibition of the Aldose reductase (AR) activity on Wistar rat lens by Quercetagetin extracted from Tagetes erects Linn and by Patuletin extracted from Tagetes patula Linn are reported. Quercetagetin inhibited AR of the rat lens by 93.9% at 10(-4) M, 76.0% at 10(-5) M and 13.3% at 10(-6) M. Patuletin inhibited AR of the rat lens by 100% at 10(-1) M, 80% at 10(-5) M and 22.7% at 10(-6) M respectively. The results show that these two flavones are lens AR Inhibitors, but further study should be done for the possibility of clinical application.
S Li; W Mao; X Cao; S Liang; Z Ding; N Li
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Yan ke xue bao = Eye science / "Yan ke xue bao" bian ji bu     Volume:  7     ISSN:  1000-4432     ISO Abbreviation:  Yan Ke Xue Bao     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1993-02-11     Completed Date:  1993-02-11     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8605666     Medline TA:  Yan Ke Xue Bao     Country:  CHINA    
Other Details:
Languages:  eng     Pagination:  29-30, 33     Citation Subset:  IM    
Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou, China.
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MeSH Terms
Aldehyde Reductase / metabolism*
Chromones / pharmacology*
Drugs, Chinese Herbal / pharmacology*
Lens, Crystalline / enzymology*
Rats, Wistar
Reg. No./Substance:
0/Chromones; 0/Drugs, Chinese Herbal; 519-96-0/patuletin; 90-18-6/quercetagetin; EC Reductase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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