Document Detail


Inhibition of rat intestinal anaphylaxis by various anti-inflammatory agents.
MedLine Citation:
PMID:  7405752     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adverse reactions to food may, in some cases, be due to IgE-mediated immune reactions to the ingested antigens. A mast cell protector has been shown to protect patients against challenge with food to which they are sensitive. An IgE-mediated intestinal anaphylaxis reaction in the rat has been developed as a model of some aspects of human food allergy. Using this model, a number of xanthones and other anti-inflammatory agents were tested for activity in inhibiting intestinal anaphylaxis. The compounds were also tested for inhibitory activity against the IgE-mediated rat passive cutaneous anaphylaxis reactions. The xanthones protected against both reactions, as did isoproterenol and cyproheptadine, while aspirin, indomethacin, and dexamethasone inhibited the intestinal but not the cutaneous reaction. This suggests that while IgE-triggered mediator release from mast cells is important in both reactions, other mechanisms may also be operative in the intestinal reaction. Furthermore, the use of xanthones and other anti-inflammatory compounds may be a useful mode of therapy in human food allergy.
Authors:
N E Byars; R W Ferraresi
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Agents and actions     Volume:  10     ISSN:  0065-4299     ISO Abbreviation:  Agents Actions     Publication Date:  1980 Jun 
Date Detail:
Created Date:  1980-10-21     Completed Date:  1980-10-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0213341     Medline TA:  Agents Actions     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  252-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anaphylaxis / prevention & control*
Animals
Anti-Inflammatory Agents / pharmacology*
Female
Immunoglobulin E / immunology
Intestinal Diseases / immunology,  prevention & control*
Mast Cells / drug effects
Passive Cutaneous Anaphylaxis / drug effects*
Prostaglandin Antagonists / pharmacology
Rats
SRS-A / physiology
Structure-Activity Relationship
Time Factors
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Prostaglandin Antagonists; 0/SRS-A; 37341-29-0/Immunoglobulin E

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