Document Detail

Inhibition of the rat hepatic mixed-function oxidases by in vivo administration of clotrimazole.
MedLine Citation:
PMID:  3363224     Owner:  NLM     Status:  MEDLINE    
The ability of the 1-substituted imidazole antifungal agent clotrimazole to inhibit the rat hepatic microsomal mixed-function oxidases was investigated in rats pretreated with either phenobarbital or 3-methylcholanthrene. When administered to 3-methylcholanthrene-pretreated animals, clotrimazole inhibited the O-deethylations of ethoxyresorufin and ethoxycoumarin. An even more marked inhibition of the dealkylation of pentoxyresorufin and O-deethylation of ethoxycoumarin was observed in phenobarbital-pretreated rats. It is concluded that administration of clotrimazole to rats gives rise to a marked inhibition of the hepatic mixed-function oxidases, and especially of the cytochrome P450 II B family of haemoproteins.
A D Rodrigues; P R Waddell; C Ioannides
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  59     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-06-09     Completed Date:  1988-06-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  403-6     Citation Subset:  IM    
Department of Biochemistry, University of Surrey, Guildford, U.K.
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MeSH Terms
Clotrimazole / pharmacology*
Cytochrome P-450 Enzyme System / antagonists & inhibitors
Drug Interactions
Imidazoles / pharmacology*
Liver / enzymology*
Mixed Function Oxygenases / antagonists & inhibitors*
Rats, Inbred Strains
Reg. No./Substance:
0/Imidazoles; 23593-75-1/Clotrimazole; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.-/Mixed Function Oxygenases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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