Document Detail


Inhibition of rat bronchiolar oxygen consumption by plasma proteins.
MedLine Citation:
PMID:  649466     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The oxygen consumption of rat bronchioles suspended in a physiological salt solution containing plasma proteins was measured with the Cartesian diver microrespirometer. The oxygen consumption of the bronchiolar tissue 100-300 and 300-400 micrometer in diam was significantly (P greater than 0.01) reduced as the protein concentration of the suspending solution was increased from the low to the high extreme of the normal plasma physiological range and as the diffusion distance through the suspending medium was increased from 25 to 50 micrometer. The reduction in the bronchiolar oxygen consumption was significantly (P greater than 0.01) reversed by using 95% oxygen-5% nitrogen instead of air as the diffusing gas in the Cartesian diver. Measurements of the oxygen diffusivity in the protein solutions using a diaphragm diffusion cell showed a large decrease in the diffusivity as the plasma protein concentration was increased over the same concentration range used in the oxygen consumption studies. These results suggest that the reduction in oxygen consumption was secondary to a decrease in oxygen diffusion and may provide at least a partial explanation for the diffusion abnormalities which exist in noncardiogenic pulmonary edema in which there is an increase in microvascular membrane permeability to proteins.
Authors:
R M Navari; J L Patterson
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  44     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1978 May 
Date Detail:
Created Date:  1978-07-15     Completed Date:  1978-07-15     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  659-65     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Proteins / physiology*
Bronchi / physiology*
Diffusion
Male
Oxygen Consumption*
Rats
Respiration
Solutions
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Solutions

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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