Document Detail


Inhibition of rat brain monoamine oxidase and succinic dehydrogenase by anticonvulsant pyrazolines.
MedLine Citation:
PMID:  3589148     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Substituted 1,5-diaryl-3(4-chlorophenyl)-delta 2-pyrazolines were synthesized and evaluated for anticonvulsant activity. Most pyrazolines (100 mg/kg) provided 20-80% protection against pentylenetetrazol-induced convulsions in mice. All compounds inhibited rat brain mitochondrial monoamine oxidase (MAO) and succinic dehydrogenase (SDH) and exhibited low toxicity as reflected by approximate LD50 values (500 to greater than 1000 mg/kg) in mice.
Authors:
N Soni; K Pande; R Kalsi; T K Gupta; S S Parmar; J P Barthwal
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  56     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-07-08     Completed Date:  1987-07-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  129-32     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anticonvulsants / pharmacology*
Brain / enzymology*
Mitochondria / enzymology
Monoamine Oxidase Inhibitors*
Pyrazoles / pharmacology*
Rats
Succinate Dehydrogenase / antagonists & inhibitors*
Chemical
Reg. No./Substance:
0/Anticonvulsants; 0/Monoamine Oxidase Inhibitors; 0/Pyrazoles; EC 1.3.99.1/Succinate Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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