Document Detail


Inhibition of rabbit erythroid 15-lipoxygenase and sheep vesicular gland prostaglandin H synthase by gallic esters.
MedLine Citation:
PMID:  1906619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gallic acid esters possessing a varying chain length of their alcohol moiety were tested for their inhibitory potencies on 15-lipoxygenase from rabbit reticulocytes and prostaglandin H synthase from sheep vesicular glands. Octyl gallate and decyl gallate proved to be the most powerful inhibitors of both enzymes showing concentrations of half-inhibition of about 0.25 mumol/l for the reticulocyte lipoxygenase and of about 25 mumol/l for the prostaglandin H synthase.
Authors:
H Luther; D Jordanov; P Ludwig; T Schewe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Die Pharmazie     Volume:  46     ISSN:  0031-7144     ISO Abbreviation:  Pharmazie     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-08-19     Completed Date:  1991-08-19     Revised Date:  2007-01-29    
Medline Journal Info:
Nlm Unique ID:  9800766     Medline TA:  Pharmazie     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  134-6     Citation Subset:  IM    
Affiliation:
Institute of Biochemistry, Medical School (Charité), Humboldt-University, Berlin.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arachidonate 15-Lipoxygenase / antagonists & inhibitors*
Cyclooxygenase Inhibitors*
Exocrine Glands / enzymology*
Gallic Acid / analogs & derivatives*,  chemical synthesis,  pharmacology*
Prostaglandins H / biosynthesis*
Rabbits
Reticulocytes / enzymology*
Sheep
Chemical
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 0/Prostaglandins H; 149-91-7/Gallic Acid; EC 1.13.11.33/Arachidonate 15-Lipoxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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