Document Detail


Inhibition of proteoglycan synthesis eliminates left-right asymmetry in Xenopus laevis cardiac looping.
MedLine Citation:
PMID:  2100995     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The heart of any vertebrate is formed from an apparently symmetric cardiac tube that loops consistently in the same direction along the left-right axis of the embryo. In the amphibian Xenopus laevis, inhibition of proteoglycan synthesis by p-nitrophenyl-beta-D-xylopyranoside during a narrow period of development from late gastrula to early neurula specifically eliminated the looping of the cardiac tube. Most of the proteoglycans synthesized during this period were heparan sulfate proteoglycans. Treatment with p-nitrophenyl-alpha-D-xylopyranoside, an analogue that does not inhibit proteoglycan synthesis, did not interfere with cardiac looping. The critical period for proteoglycan synthesis was coincident with the migration of cardiac primordia to the ventral midline. The inhibition of cardiac looping was further explored in explants of cardiac primordia and anterioventral ectoderm. In recombinate embryos in which half the embryo, and thus one of the two heart primordia, was treated with p-nitrophenyl-beta-D-xylopyranoside, and the other half was untreated, cardiac looping occurred normally. It is proposed that the left-right axis in Xenopus, as reflected in cardiac looping, is established early in development, and that proteoglycan synthesis is involved in the transduction of left-right axial information to the cardiac primordia during migration.
Authors:
H J Yost
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  110     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1991-05-28     Completed Date:  1991-05-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  865-74     Citation Subset:  IM    
Affiliation:
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cells, Cultured
Glycosides / metabolism*
Heart / embryology*
Mesoderm / physiology
Morphogenesis
Proteoglycans / biosynthesis*
Xenopus laevis / embryology*
Grant Support
ID/Acronym/Agency:
GM19363/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Glycosides; 0/Proteoglycans; 0/xylosides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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