| Inhibition of protein kinase mζ disrupts the stable spatial discharge of hippocampal place cells in a familiar environment. | |
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MedLine Citation:
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PMID: 23035087 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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It is widely held that spatial computations in the rodent hippocampus require the location-specific discharge of place cells that together form a stable cognitive map used to solve and perform spatial tasks. It is not known, however, if map stability requires persistent hippocampal synaptic strength changes that are vulnerable to blockade of protein kinase Mζ (PKMζ) phosphorylation activity, a manipulation that reverses hippocampal LTP and disrupts multiple forms of long-term memory. Here we report that acute intrahippocampal inhibition of PKMζ disrupts place cell activity in a familiar environment, where the map is expected to be stable. After this disruption, new, stable spatial firing patterns can later form, but the new and original maps are unrelated even though the rat is exposed to a constant environment. We therefore propose that the previously demonstrated erasure of stored spatial memory and the disruption of place cell firing are parallel effects of PKMζ blockade. We similarly propose that the known sparing of new spatial memory formation depends on the sparing of new map formation. On these bases, we argue that the loss of the map used to perform a practiced spatial task leads to behavioral performance deficits, and that synaptic plasticity maintained by PKMζ, which stabilizes the map, is essential for the proper expression of spatial memory. |
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Authors:
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Jeremy M Barry; Bruno Rivard; Steven E Fox; Andre A Fenton; Todd C Sacktor; Robert U Muller |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 32 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 13753-62 Citation Subset: IM |
Affiliation:
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Department of Physiology and Pharmacology, State University of New York, Downstate Medical Center, Brooklyn, New York 11203, The Robert F. Furchgott Center for Neural & Behavioral Science, State University of New York, Downstate Medical Center, Brooklyn, New York 11203, and Center for Neural Science, New York University, New York, New York 10003. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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