Document Detail

Inhibition of prostanoid-mediated contraction to endothelin-1 after hypoxia in rat aorta.
MedLine Citation:
PMID:  11438307     Owner:  NLM     Status:  MEDLINE    
The role of the thromboxane A(2)/prostaglandin H(2) receptor in endothelin-1 contraction was investigated in aortic rings from rats exposed to normoxia (21% O(2)) or hypoxia (10% O(2)) for 12 h. Indomethacin (10 microM) and SQ 29,548 (0.1 microM, thromboxane A(2)/prostaglandin H(2) receptor antagonist) reduced maximum tension and increased EC(50) in endothelium-intact and -denuded rings from normoxic animals. Neither inhibitor had any effect on rings from hypoxic rats. Thromboxane A(2) and/or prostaglandin H(2) contribute to the response to endothelin-1 in aortas from normoxic rats but not from rats exposed to hypoxia. Loss of prostanoid-enhancement of endothelin-1 contraction contributes to impair vascular reactivity after hypoxia.
A J Trang; H Teoh; M E Ward
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  423     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-07-04     Completed Date:  2001-08-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  57-61     Citation Subset:  IM    
Division of Respirology and Terrence Donnelly Research Laboratories, St. Michael's Hospital, Rm. 6042 Bond Wing, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8.
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MeSH Terms
Acetylcholine / pharmacology
Anoxia / physiopathology*
Aorta, Thoracic / drug effects*,  physiology
Dose-Response Relationship, Drug
Endothelin-1 / pharmacology*
Endothelium, Vascular / physiology
Hydrazines / pharmacology
Phenylephrine / pharmacology
Rats, Sprague-Dawley
Receptors, Prostaglandin / antagonists & inhibitors,  physiology*
Receptors, Thromboxane A2, Prostaglandin H2
Vasoconstriction / drug effects*
Vasoconstrictor Agents / pharmacology
Vasodilator Agents / pharmacology
Reg. No./Substance:
0/Endothelin-1; 0/Hydrazines; 0/Receptors, Prostaglandin; 0/Receptors, Thromboxane A2, Prostaglandin H2; 0/Vasoconstrictor Agents; 0/Vasodilator Agents; 51-84-3/Acetylcholine; 59-42-7/Phenylephrine; 98299-61-7/SQ 29548

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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