Document Detail

Inhibition of prostaglandin synthesis does not alter the decrease in pre-capillary resistance in the human calf in response to small cumulative increases in venous congestion.
MedLine Citation:
PMID:  15898957     Owner:  NLM     Status:  MEDLINE    
The decrease in pre-capillary resistance in the human calf during gradual cumulative increases in venous congestion pressure has been proposed to represent vasodilator signalling between the venous and arterial microcirculations. The present study investigated whether prostaglandins are involved in this local flow regulation by measuring calf blood flow and microvascular filtration capacity using strain gauge plethysmography in young male subjects before (baseline) and after taking either ibuprofen, an inhibitor of prostaglandin synthesis (1600 mg over 2 days), or placebo. At baseline, inflation of a thigh cuff to 50 mmHg in steps of 10 mmHg, each held for 5 min, did not decrease arterial inflow, confirming a reduction of pre-capillary resistance. Ibuprofen reduced resting calf blood flow by 35% (P<0.001), but flow at a Pcuff (cuff pressure) of 50 mmHg was 97% of this value, i.e. pre-capillary resistance had decreased to the same extent as before inhibition of prostaglandin synthesis. Ibuprofen also reduced microvascular filtration capacity (2.98+/-1.20 compared with 3.71+/-0.89 ml.min-1.100 ml-1.mmHg-1x10(-3); P<0.05), probably due to a combination of reduced arterial inflow and lower venous pressure (8.5+/-5.2 compared with 12.6+/-2.8 mmHg; P<0.05) that moderated capillary hydrostatic pressure to override direct effects of inhibition of prostaglandin synthesis on permeability. Placebo was without effect on any measurement. It is unlikely therefore that prostaglandin-mediated vasodilator signals, which have been demonstrated between paired veins and arteries, are important in local vasodilation in response to venous congestion.
Stephen I Anderson; Margaret D Brown
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  109     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-17     Completed Date:  2005-12-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  303-9     Citation Subset:  IM    
School of Sport and Exercise Sciences, University of Birmingham, Birmingham B15 2TT, UK.
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MeSH Terms
Blood Pressure / physiology
Capillary Resistance / drug effects,  physiology*
Heart Rate / physiology
Ibuprofen / pharmacology
Leg / blood supply*
Prostaglandin Antagonists / pharmacology
Prostaglandins / biosynthesis*,  physiology
Regional Blood Flow / drug effects
Signal Transduction / physiology
Vasodilation / drug effects,  physiology
Venous Pressure / physiology
Reg. No./Substance:
0/Prostaglandin Antagonists; 0/Prostaglandins; 15687-27-1/Ibuprofen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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