Document Detail

Inhibition of prostaglandin-mediated ocular inflammatory responses by 4-biphenylacetic acid.
MedLine Citation:
PMID:  1086849     Owner:  NLM     Status:  MEDLINE    
4-Biphenylacetic acid (BPAA),a prostaglandin-synthesis inhibitor, was tested for its effects on prostaglandin-related, laboratory models of ocular inflammation. Topically applied, BPAA inhibited arachidonic acid, but not prostaglandin E-induced increases in rabbit intraocular pressure (IOP). BPAA inhibited the IOP response to alkali burn and altered IOP changes following paracentesis. In vitro, BPAA inhibited prostaglandin production from arachidonic acid in cell-free preparations of rabbit uvea. It is suggested that BPAA may be useful for the therapy of ocular inflammatory disease.
E L Tolman; R Partridge; T O Myers; J E Birnbaum
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Investigative ophthalmology     Volume:  15     ISSN:  0020-9988     ISO Abbreviation:  Invest Ophthalmol     Publication Date:  1976 Dec 
Date Detail:
Created Date:  1977-01-28     Completed Date:  1977-01-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0374730     Medline TA:  Invest Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1005-8     Citation Subset:  IM    
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MeSH Terms
Acetic Acids / pharmacology,  therapeutic use*
Biphenyl Compounds / pharmacology,  therapeutic use
Disease Models, Animal
Endophthalmitis / chemically induced,  prevention & control*
Intraocular Pressure / drug effects
Prostaglandin Antagonists
Prostaglandins* / biosynthesis
Reg. No./Substance:
0/Acetic Acids; 0/Biphenyl Compounds; 0/Prostaglandin Antagonists; 0/Prostaglandins

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