Document Detail


Inhibition of prostacyclin and platelet thromboxane A2 after low-dose aspirin.
MedLine Citation:
PMID:  7003384     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To compare the inhibitory effects of aspirin on prostaglandin synthesized by vessel walls and platelets, we obtained vein segments from five subjects before they were given 150 or 300 mg of aspirin and at various intervals afterward. We then measured prostacyclin (PGI2) synthesis with a radioimmunoassay for its stable metabolite, 6-keto-prostaglandin F1 alpha. Platelet production of thromboxane A2 was measured with a radioimmunoassay for its stable metabolite, thromboxane B2. Two hours after aspirin had been given, 81 to 100 per cent inhibition of PGI2 synthesis was demonstrated; 86 per cent inhibition was still evident in one subject tested eight hours after administration. Simultaneously, platelet production of thromboxane B2 was completely inhibited for more than 24 hours. We conclude that there is little difference between the initial inhibitory response of platelet cyclooxygenase and that of vessel-wall cyclooxygenase to these doses of aspirin. Our results also indicate that in male subjects the prolonged template bleeding time after aspirin is not the consequence of selective inhibition of platelet production of thromboxane.
Authors:
F E Preston; S Whipps; C A Jackson; A J French; P J Wyld; C J Stoddard
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The New England journal of medicine     Volume:  304     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1981-02-19     Completed Date:  1981-02-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  76-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aspirin / administration & dosage*,  pharmacology
Bleeding Time
Blood Platelets / drug effects,  metabolism*
Epoprostenol / antagonists & inhibitors*,  biosynthesis
Female
Humans
Male
Platelet Aggregation / drug effects
Prostaglandin Antagonists*
Thromboxane A2 / biosynthesis*
Thromboxanes / biosynthesis*
Veins / metabolism
Chemical
Reg. No./Substance:
0/Prostaglandin Antagonists; 0/Thromboxanes; 35121-78-9/Epoprostenol; 50-78-2/Aspirin; 57576-52-0/Thromboxane A2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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