Document Detail

Inhibition of proliferation of a colon cancer cell line by indole-3-carbinol.
MedLine Citation:
PMID:  12780618     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To observe the effect of Indole-3-carbinol (I3C), a naturally occurring component of cruciferous vegetables, on cell proliferation of a colon cancer cell line. METHODS: Cell proliferation was measured using three different methods; 3H-thymidine incorporation, cell count and colourimetric assay. RESULTS: Each method of measurement revealed that I3C significantly reduced cell proliferation at concentrations of > 0.1 mM. CONCLUSION: The present study demonstrates for the first time the capacity of indole-3-carbinol to inhibit cell proliferation of a colon cancer cell line.
H. R Frydoonfar; D. R McGrath; A. D Spigelman
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Publication Detail:
Journal Detail:
Title:  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland     Volume:  4     ISSN:  1463-1318     ISO Abbreviation:  Colorectal Dis     Publication Date:  2002 May 
Date Detail:
Created Date:  2003-Jun-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883611     Medline TA:  Colorectal Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  205-207     Citation Subset:  -    
Discipline of Surgical Science Faculty of Medicine and Health Sciences The University of Newcastle.
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