Document Detail


Inhibition of prolactin release by stimulation of presynaptic serotonin autoreceptors.
MedLine Citation:
PMID:  7154858     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of 5-methoxy-N,N-dimethyltryptamine (5-MeODMT), a serotonin agonist with a preferential action on presynaptic autoreceptors, on prolactin release in male rats was determined. Basal serum prolactin levels were not altered after administration of 1.0, 2.0, 5.0, 10.0 or 20.0 mg/kg of 5-MeODMT. Pretreatment with 5-MeODMT reduced prolactin release by agents that depend on serotonergic neurotransmission for part of their prolactin release stimulation. Prolactin release in response to L-5-hydroxytryptophan (5-HTP) or morphine was significantly reduced by pretreatment of the rats with 5-MeODMT. The results of this experiment indicate that 5-MeODMT acts as a presynaptic serotonin autoreceptor stimulant and not as a post-synaptic serotonin agonist on the neuronal systems that control prolactin release.
Authors:
J A Clemens; M E Roush
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  31     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1982 Dec 
Date Detail:
Created Date:  1983-03-17     Completed Date:  1983-03-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2641-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Stem / metabolism*
Depression, Chemical
Male
Methoxydimethyltryptamines / pharmacology
Piperazines / pharmacology
Prolactin / blood*
Quipazine / pharmacology
Raphe Nuclei / metabolism*
Rats
Rats, Inbred Strains
Receptors, Serotonin / drug effects*
Chemical
Reg. No./Substance:
0/Methoxydimethyltryptamines; 0/Piperazines; 0/Receptors, Serotonin; 15532-75-9/1-(3-trifluoromethylphenyl)piperazine; 4774-24-7/Quipazine; 6640-24-0/1-(3-chlorophenyl)piperazine; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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