Document Detail

Inhibition of prednisolone osteopathy by diphosphonate (EHDP) in an animal experiment
MedLine Citation:
PMID:  2499303     Owner:  NLM     Status:  MEDLINE    
The application of a low dose of prednisolone (0.4 mg per kg body weigh and day) in young hamsters leads to a loss of bone mass. This effect is inhibited by the administration of the diphosphonate EHDP (6.2 mg per kg body weight and day). The total volume of the limb bones is increased. The application of a high dose of prednisolone (40 mg per kg body weight and day) induces a severe osteopathy. These pathological bone changes couldn't be prevented by EHDP, but there was a significant shift of the investigated parameters into the direction of normalization.
K Trzenschik; K Lindenhayn; G Bühler
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Beiträge zur Orthopädie und Traumatologie     Volume:  36     ISSN:  0005-8149     ISO Abbreviation:  Beitr Orthop Traumatol     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-07-05     Completed Date:  1989-07-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372503     Medline TA:  Beitr Orthop Traumatol     Country:  GERMANY, EAST    
Other Details:
Languages:  ger     Pagination:  81-91     Citation Subset:  IM    
Vernacular Title:
Inhibierung der Prednisolon-Osteopathie durch Diphosphonat (EHDP) im Tierexperiment.
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MeSH Terms
Bone and Bones / drug effects
Etidronic Acid / administration & dosage*
Osteoporosis / chemically induced*,  prevention & control
Prednisolone / toxicity*
Reg. No./Substance:
2809-21-4/Etidronic Acid; 50-24-8/Prednisolone

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