Document Detail

Inhibition of poly(ADP-ribose) synthetase by unsaturated fatty acids, vitamins and vitamin-like substances.
MedLine Citation:
PMID:  2139856     Owner:  NLM     Status:  MEDLINE    
Various vitamins and vitamin-like substances inhibited the activity of poly(ADP-ribose) synthetase in vitro. The most potent were essential fatty acids, i.e. arachidonic acid, linoleic acid, and linolenic acid; their 50% inhibitory concentrations (IC50) were 44-110 microM, indicating a higher potency than nicotinamide, a well-known vitamin inhibitor (IC50 = 210 microM). Vitamins K3, K1, and retinal were the next strongest inhibitors, followed by alpha-lipoic acid, coenzyme Q0, and pyridoxal 5-phosphate. Nicotinamide and vitamin K3 exhibited mixed-type inhibition with respect to NAD+, while arachidonic acid exhibited dual inhibitions, competitive at 50 microM and mixed-type at 100 microM.
M Banasik; H Komura; K Ueda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  263     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-06-11     Completed Date:  1990-06-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  222-4     Citation Subset:  IM    
Department of Clinical Science and Laboratory Medicine, Kyoto University Faculty of Medicine, Japan.
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MeSH Terms
Arachidonic Acid
Arachidonic Acids / pharmacology
Fatty Acids, Unsaturated / pharmacology*
Niacinamide / pharmacology
Poly(ADP-ribose) Polymerases / antagonists & inhibitors*
Thymus Gland / enzymology
Vitamins / pharmacology*
Reg. No./Substance:
0/Arachidonic Acids; 0/Fatty Acids, Unsaturated; 0/Vitamins; 506-32-1/Arachidonic Acid; 98-92-0/Niacinamide; EC Polymerases

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