Document Detail

Inhibition of platelet thrombus formation by chlorpromazine acting to diminish haemolysis.
MedLine Citation:
PMID:  492337     Owner:  NLM     Status:  MEDLINE    
There is increasing evidence that the sudden, unpredicatable event initiating myocardial infarction is fissuring of an atherosclerotic plaque. The resulting haemorrhage into the arterial wall produces obstructive platelet thrombi, just as arterial haemorrhages elsewhere produce haemostatic platelet plugs. It has been suggested that such platelet aggregation depends on ADP originating in red cells which are subjected to excessive haemodynamic stress at the site of haemorrhage. The release of ADP from red cells has been demonstrated in vitro in equivalent condtions of shear stress; and other mechansims, such as activation by collagen, cannot account for the rapidity with which the platelets react. One of us (G.V.R.B.) has suggested that drugs capable of counteracting haemolysis might diminish the activating effect of erythrocytes on platelets and so inhibit their aggregation as thrombi. Thus, chlorpromazine, added to human blood at concentrations which diminish haemoylsis but do not directly affect platelet aggregation, prolonged the 'bleeding time' from small holes in artificial vessels where extravasation is terminated, as in living arterioles, by aggregated platelets. The bleeding time was also prolonged by apyrase, consistent with the conclusion that the chlorpromazine acted through decreasing plasma ADP. We show here that this occurs through the anti-haemolytic action of chlorpromazine.
G V Born; A Wehmeier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nature     Volume:  282     ISSN:  0028-0836     ISO Abbreviation:  Nature     Publication Date:  1979 Nov 
Date Detail:
Created Date:  1979-12-29     Completed Date:  1979-12-29     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  212-3     Citation Subset:  IM    
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MeSH Terms
Adenosine Diphosphate / blood
Blood Coagulation / drug effects*
Chlorpromazine / pharmacology*
Depression, Chemical
Dose-Response Relationship, Drug
Hemoglobins / metabolism
Hemolysis / drug effects*
Myocardial Infarction / prevention & control
Platelet Aggregation / drug effects
Reg. No./Substance:
0/Hemoglobins; 50-53-3/Chlorpromazine; 58-64-0/Adenosine Diphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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