Document Detail

Inhibition of platelet aggregation by myeloid leukaemic cells demonstrated in vitro.
MedLine Citation:
PMID:  3478076     Owner:  NLM     Status:  MEDLINE    
The effect of myeloid leukaemic cells, cells of the promyelocytic cell line HL-60 and normal polymorphonuclear granulocytes (PMN), enclosed in dialysis tubes, on the aggregation of allogeneic normal platelets after induction with arachidonic acid (AA) and with adenosine diphosphate (ADP) was investigated in vitro. Inhibition of aggregation was seen after preincubation of the platelets with leukaemic blood or bone marrow cells from 7/14 patients belonging to various FAB groups and with HL-60 cells, but not with normal PMN (14/14 cases). A dose-dependent inhibition was seen after lysis of some leukaemic cells with anti-human rabbit antiserum and active complement. Lysis of normal PMN inhibited platelet aggregation slightly and inconstantly and only at higher cell concentrations. Platelet inhibitory activity was not related to a higher rate of metabolism of the leukaemic cells which inhibited platelet aggregation since they did not differ from the cells not inhibiting aggregation with respect to heat production. Neither was a non-specifically increased cell membrane permeability the cause of the release of platelet inhibitory factor(s) since the release of 51Cr-labelled leukaemic cells was not related to the inhibition of platelet aggregation.
R Fäldt; J Ankerst; E Zoucas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of haematology     Volume:  66     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-12-16     Completed Date:  1987-12-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  529-34     Citation Subset:  IM    
Department of Internal Medicine, University of Lund, Sweden.
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MeSH Terms
Adenosine Diphosphate / pharmacology
Arachidonic Acids / pharmacology
Bone Marrow / pathology
Cell Line
Dose-Response Relationship, Immunologic
Leukemia, Myeloid, Acute / blood,  pathology*
Platelet Aggregation / drug effects*
Reg. No./Substance:
0/Arachidonic Acids; 58-64-0/Adenosine Diphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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