| Inhibition of plasma extravasation after burns by D-myo-inositol-1,2,6-trisphosphate using digital image colour analysis. | |
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MedLine Citation:
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PMID: 9646362 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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D-myo-inositol-1,2,6-triphosphate (1,2,6-IP3) has beneficial effects in experimental, progressive burn-induced ischaemia and oedema. A 1 cm2 full-thickness burn was made in the skin of 20 rats with a hot aluminium rod followed by infusion of 1,2,6-IP3 (60 mg.kg.-1 h-1) or isotonic saline (n = 10 in each group). One hour later Evans blue was injected intravenously. Colour photographs of the area of the burn were taken in a standard manner before the burn and at intervals for three hours afterwards. The photographs were analysed by digital image colour analysis using normalised red-green-blue values. The increase in normalised blue values between 60 and 180 minutes after the burn was significantly reduced in animals treated with 1,2,6-IP3 compared with control animals (p < 0.001). Spectrophotometric analysis of extravasated Evans blue in the skin 180 minutes after the burn showed that it had been significantly inhibited by treatment with 1,2,6-IP3 (p < 0.001). In conclusion, digital image analysis allowed repeated evaluation over time and confirmed previous data about the ability of 1,2,6-IP3 to inhibit extravasation of plasma after burns. |
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Authors:
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P Tarnow; A Jönsson; U Mattsson; G Rimbäck; J Cassuto |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of plastic and reconstructive surgery and hand surgery / Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi Volume: 32 ISSN: 0284-4311 ISO Abbreviation: Scand J Plast Reconstr Surg Hand Surg Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-09-03 Completed Date: 1998-09-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8707869 Medline TA: Scand J Plast Reconstr Surg Hand Surg Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 141-6 Citation Subset: IM |
Affiliation:
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Department of Plastic Surgery, Sahlgrenska University Hospital, Göteborg, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Burns / complications, physiopathology* Capillary Permeability / drug effects* Edema / etiology, physiopathology Evans Blue / diagnostic use Extravasation of Diagnostic and Therapeutic Materials Image Processing, Computer-Assisted* Inositol Phosphates / pharmacology* Male Photography Rats Rats, Sprague-Dawley Spectrophotometry |
| Chemical | |
Reg. No./Substance:
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0/Inositol Phosphates; 28841-62-5/inositol 1,2,6-triphosphate; 314-13-6/Evans Blue |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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