Document Detail

Inhibition of phagolysosome fusion is localized to Chlamydia psittaci-laden vacuoles.
MedLine Citation:
PMID:  7019080     Owner:  NLM     Status:  MEDLINE    
Intracellular survival of Chlamydia psittaci is in part dependent on the ability of the organism to thwart phagolysosome formation. Circumvention of phagolysosome fusion could be either localized to chlamydia-laden vacuoles or generalized to all phagosomes in the host cell. To determine which of these modes is in operation the ability of chlamydia elementary and reticulate bodies to protect Saccharomyces cerevisiae from degradation in macrophage phagolysosomes was examined via acridine orange and Giemsa staining. No statistically significant difference was evident between the amount of fusion observed in coinfected macrophages and those infected with yeast cells alone. This was ot dependent on some unique interaction between the chlamydia and the yeast cells since viable count studies to determine the protection of a second organism, Escherichia coli, also failed to show significantly different amounts of inactivation of the bacteria by macrophages in the presence of C. psittaci. Therefore, the inhibition of phagolysosome fusion is localized to chlamydia-laden phagosomes.
L G Eissenberg; P B Wyrick
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Infection and immunity     Volume:  32     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  1981 May 
Date Detail:
Created Date:  1981-09-15     Completed Date:  1981-09-15     Revised Date:  2010-09-13    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  889-96     Citation Subset:  IM    
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MeSH Terms
Chlamydophila psittaci / physiology*
Escherichia coli / physiology
Lysosomes / physiology*
Macrophages / microbiology
Organoids / microbiology*
Saccharomyces cerevisiae / physiology
Vacuoles / microbiology*,  physiology
Grant Support

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